Evidence map›Paper›PMID 30373434›Full record

ArticleAmerican journal of men's health

The Role of FTO Genotype in the Association Between FTO Gene Expression and Anthropometric Measures in Obese and Overweight Adolescent Boys.

Saeid Doaei, Naser Kalantari, Nastaran Keshavarz Mohammadi, Pantea Izadi, Maryam Gholamalizadeh, Hassan Eini-Zinab, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Rahim Najafi and 3 more

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In one paragraph

Article in American journal of men's health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Altered Expression of theNutrients · 2025
    Article
  3. Association between FTO polymorphism and COVID-19 mortality among older adults: A population-based cohort study.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  4. Review
  5. Association of fat mass and obesity-associated (Journal of diabetes and metabolic disorders · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Saeid Doaei1 Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Naser Kalantari4 Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nastaran Keshavarz Mohammadi5 Department of Public Health, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pantea Izadi6 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Maryam Gholamalizadeh3 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hassan Eini-Zinab4 Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tuire Salonurmi7 Department of Internal Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland.
Alireza Mosavi Jarrahi3 Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahram Rafieifar8 Health Promotion and Education Department, Ministry of Health, Tehran, Iran.
Rahim Najafi9 Deputy of Education and Training of Naja, Tehran, Iran.
Mahnaz Sadeghypor10 Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Ghasem Azizi Tabesh11 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mark O Goodarzi12 Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Shahid Beheshti University of Medical Sciences · IRCedars-Sinai Medical Center · USIslamic Azad University, Science and Research Branch · IRMinistry of Health and Medical Education · IRNational Nutrition and Food Technology Research Institute · IRTehran University of Medical Sciences · IRUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of FTO genotype in the effect of FTO gene expression level on change in body mass index and body composition has not been studied. This study aimed to investigate the role of FTO genotype in the association between change in the expression level of the FTO gene with changes in anthropometric measurements in obese and overweight adolescent boys. Eighty-four boys aged 12 to 16 years participated in this longitudinal study. A bioimpedance analyzer (BIA) was used to estimate percentage of body fat (%body fat) and percentage of skeletal muscle (%skeletal muscle). The FTO gene expression level in peripheral blood mononuclear cells (PBMCs) was assessed using quantitative Real Time PCR (qPCR). The DNA samples were genotyped for the FTO gene polymorphisms by DNA sequencing. All measurements were performed at baseline and after intervention. A significant association was observed between the level of gene expression and %skeletal muscle. The gene expression fold change was significantly associated with change in %skeletal muscle in AA or AG genotype carriers (β = 0.34, p = .02). No significant association was detected between the change in FTO gene expression with change in anthropometric indices in GG genotype carriers. In conclusion, the association between FTO gene expression and body composition can be influenced by FTO genotype. Future studies are required to assess the interactions between FTO genotype, FTO gene expression in different tissues, and body composition.

Indexed as

Gene Expression RegulationAdolescentAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnthropometryBody CompositionBody Mass IndexChildCohort StudiesGenotypeHumansIncidenceLinear ModelsLongitudinal StudiesMaleOverweightPediatric ObesityAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanbody fatbody mass indexFTOgene expressionobesityskeletal muscle

Identifiers

PMID30373434
PMCPMC6771125
OpenAlexW2899205264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.