Evidence map›Paper›PMID 30373326›Full record

ArticleMolecules (Basel, Switzerland)2018

TrypanocidalActivity of Natural Sesquiterpenoids Involves Mitochondrial Dysfunction, ROS Production and Autophagic Phenotype in Trypanosomacruzi.

Ana Cristina Souza Bombaça, Daniela Von Dossow, Juliana Magalhães Chaves Barbosa, Cristian Paz, Viviana Burgos, Rubem Figueiredo Sadok Menna-Barreto

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Plants (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Meroterpenoids fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  6. Article
  7. Article
  8. Drimane Sesquiterpene Alcohols with Activity againstInternational journal of molecular sciences · 2022
    Article
  9. Drimane Sesquiterpene Aldehydes ControlInternational journal of molecular sciences · 2022
    Article
  10. Plant Terpenoids as Hit Compounds against Trypanosomiasis.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  11. Review
  12. Article
  13. Antifungal Effects of Drimane Sesquiterpenoids Isolated fromApplied and environmental microbiology · 2020
    Article
  14. Article
  15. Trypanocidal Mechanism of Action andInternational journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ana Cristina Souza BombaçaLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, 21040-360, Brazil. anabombaca@gmail.com.
Daniela Von DossowDepartamento de Ciencias Químicas y Recursos Naturales, Universidad de La Frontera, Temuco,4811230, Chile. julianabmunirio@gmail.com.
Juliana Magalhães Chaves BarbosaLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, 21040-360, Brazil. d.vondossow01@ufromail.cl.
Cristian PazDepartamento de Ciencias Químicas y Recursos Naturales, Universidad de La Frontera, Temuco,4811230, Chile. cristian.paz@ufrontera.cl.
Viviana BurgosDepartamento de Ciencias Químicas y Recursos Naturales, Universidad de La Frontera, Temuco,4811230, Chile. viviana.burgos@ufrontera.cl.
Rubem Figueiredo Sadok Menna-BarretoLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, 21040-360, Brazil. rubemsadok@gmail.com.
Fundação Oswaldo Cruz · BRUniversidad de La Frontera · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease is a neglected tropical disease that is caused by the protozoan

Indexed as

AutophagyMitochondriaMolecular StructureReactive Oxygen SpeciesSesquiterpenesTrypanocidal AgentsTrypanosoma cruziReactive Oxygen SpeciesSesquiterpenesTrypanocidal Agentsautophagychagas diseasechemotherapymitochondriasesquiterpenoidsTrypanosoma cruzi

Identifiers

PMID30373326
PMCPMC6278339
OpenAlexW2898333881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.