Evidence map›Paper›PMID 30373276›Full record

ArticleInternational journal of molecular sciences2018

Administration of Downstream ApoE Attenuates the Adverse Effect of Brain ABCA1 Deficiency on Stroke.

Xiaohui Wang, Rongwen Li, Alex Zacharek, Julie Landschoot-Ward, Fengjie Wang, Kuan-Han Hank Wu, Michael Chopp, Jieli Chen, Xu Cui

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaohui WangDepartment of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA. 163.wangxh@163.com.
Rongwen LiDepartment of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA. rli3@hfhs.org.
Alex ZacharekDepartment of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA. Alexzacharek@gmail.com.
Julie Landschoot-WardDepartment of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA. JLandsc@hfhs.org.
Fengjie WangDepartment of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA. fwang2@hfhs.org.
Kuan-Han Hank WuDepartment of Physics, Oakland University, Rochester, MI 48309, USA. kwu1@hfhs.org.
Michael ChoppDepartment of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA. mchopp1@hfhs.org.
Jieli ChenDepartment of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA. jchen4@hfhs.org.ORCID 0000-0001-5446-9101
Xu CuiDepartment of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA. xcui1@hfhs.org.ORCID 0000-0002-6937-6191
Henry Ford Hospital · USOakland University · US

Funding

ABCA1 regulates white matter remodeling and oligodendrogenesis after strokeR01NS092917 · NINDS · HENRY FORD HEALTH SYSTEM · PI CUI, XU · 2015 to 2019
$1.6M
MiR-126/ABCA1 mediates exosome induced neurorestorative effects after stroke in T2DM miceR01NS099030 · NINDS · HENRY FORD HEALTH SYSTEM · PI CHEN, JIELI · 2016 to 2018
$984k
National Institute of Neurological Disorders and Stroke R01NS092917, R01NS099030 and R01NS088656NINDS NIH HHS R01 NS092917NINDS NIH HHS R01 NS099030
6 · The paper itself

Abstract

The ATP-binding cassette transporter member A1 (ABCA1) and apolipoprotein E (ApoE) are major cholesterol transporters that play important roles in cholesterol homeostasis in the brain. Previous research demonstrated that specific deletion of brain-ABCA1 (ABCA1

Indexed as

AnimalsApolipoproteins EATP Binding Cassette Transporter 1BrainCells, CulturedCholesterol, HDLHumansLDL-Receptor Related ProteinsMaleMiceMice, Inbred C57BLNeuronsStrokeAbca1 protein, mouseApolipoproteins EATP Binding Cassette Transporter 1Cholesterol, HDLLDL-Receptor Related Proteinslow density lipoprotein receptor-related protein 8apolipoprotein Eapolipoprotein E receptor 2ATP-binding cassette transporter A1high density lipoproteinmotor functionstroke

Identifiers

PMID30373276
PMCPMC6274914
OpenAlexW2898566544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.