Evidence map›Paper›PMID 30373263›Full record

ReviewInternational journal of molecular sciences2018

Cellular Signaling Pathways Activated by Functional Graphene Nanomaterials.

Anna Piperno, Angela Scala, Antonino Mazzaglia, Giulia Neri, Rosamaria Pennisi, Maria Teresa Sciortino, Giovanni Grassi

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. SERS Sensing Properties of New Graphene/Gold Nanocomposite.Nanomaterials (Basel, Switzerland) · 2019
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna PipernoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le F. Stagno d'Alcontres 31, 98166 Messina, Italy. apiperno@unime.it.ORCID 0000-0001-6004-5196
Angela ScalaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le F. Stagno d'Alcontres 31, 98166 Messina, Italy. ascala@unime.it.ORCID 0000-0003-2171-9033
Antonino MazzagliaCNR-ISMN c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences of the University of Messina, V.le F. Stagno d'Alcontres 31, 98166 Messina, Italy. amazzaglia@unime.it.ORCID 0000-0002-3140-5655
Giulia NeriDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le F. Stagno d'Alcontres 31, 98166 Messina, Italy. nerig@unime.it.ORCID 0000-0002-4458-0022
Rosamaria PennisiDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le F. Stagno d'Alcontres 31, 98166 Messina, Italy. rpennisi@unime.it.ORCID 0000-0003-3474-6057
Maria Teresa SciortinoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le F. Stagno d'Alcontres 31, 98166 Messina, Italy. mtsciortino@unime.it.ORCID 0000-0002-8519-7724
Giovanni GrassiDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, V.le F. Stagno d'Alcontres 31, 98166 Messina, Italy. ggrassi@unime.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The paper reviews the network of cellular signaling pathways activated by Functional Graphene Nanomaterials (FGN) designed as a platform for multi-targeted therapy or scaffold in tissue engineering. Cells communicate with each other through a molecular device called signalosome. It is a transient co-cluster of signal transducers and transmembrane receptors activated following the binding of transmembrane receptors to extracellular signals. Signalosomes are thus efficient and sensitive signal-responding devices that amplify incoming signals and convert them into robust responses that can be relayed from the plasma membrane to the nucleus or other target sites within the cell. The review describes the state-of-the-art biomedical applications of FGN focusing the attention on the cell/FGN interactions and signalosome activation.

Indexed as

AnimalsDrug CarriersGraphiteHumansNanostructuresSignal TransductionTissue ScaffoldsDrug CarriersGraphitedoxorubicin/graphenegraphene/cell interactionsgraphene signalinggraphene uptakenanomaterials

Identifiers

PMID30373263
PMCPMC6274994

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.