ReviewLife (Basel, Switzerland)2018
The Distinctive Regulation of Cyanobacterial Glutamine Synthetase.
Review in Life (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- Photosynthetic production of glutamine through metabolic analysis-based engineering ofMetabolic engineering communications · 2026Article
- Engineering primary metabolism for sustainable production of isoprene in Synechocystis sp. PCC 6803.Microbial cell factories · 2026Article
- Diel transcriptional dynamics of a marine sponge and its microbiome in a natural environment.Animal microbiome · 2026Article
- A novel lineage of large aquatic bacteriophages identified through metagenomics.Archives of virology · 2025Article
- Tracking putativemSystems · 2025Article
- Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signaling cascade.iScience · 2025Article
- Article
- Loss of Arabidopsis ACR11 results in altered C/N balance and high sensitivity to nitrogen toxicity.Frontiers in plant science · 2025Article
- Biotechnological Applications of Cyanobacteria: Synechocystis and Synechococcus Strains.Advances in biochemical engineering/biotechnology · 2025Review
- Integrated Proteomics and Metabolomics Reveal Altered Metabolic Regulation ofACS applied materials & interfaces · 2024Article
- Antisense RNA regulates glutamine synthetase in a heterocyst-forming cyanobacterium.Plant physiology · 2024Article
- Effects of nitrate and ammonium on assimilation of nitric oxide by Heterosigma akashiwo.Scientific reports · 2023Article
- Glutamine synthetase mRNA releases sRNA from its 3'UTR to regulate carbon/nitrogen metabolic balance ineLife · 2022Article
- Polyamine and Ethanolamine Metabolism in Bacteria as an Important Component of Nitrogen Assimilation for Survival and Pathogenicity.Medical sciences (Basel, Switzerland) · 2022Review
- Effects of Light and Temperature on the Metabolic Profiling of Two Habitat-Dependent Bloom-Forming Cyanobacteria.Metabolites · 2022Article
- The sRNA NsiR4 fine-tunes arginine synthesis in the cyanobacteriumRNA biology · 2022Article
- Integrative analysis of the salt stress response in cyanobacteria.Biology direct · 2021Article
- Genetic Responses of Metabolically ActiveMicroorganisms · 2021Article
- Quantitative Proteomic and Microcystin Production Response ofMicroorganisms · 2021Article
- The Novel PmBio · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria, is subject to exquisite regulation at multiple levels, among them gene expression regulation to control GS abundance, as well as feedback inhibition and covalent modifications to control enzyme activity. Intriguingly, the GS of the ecologically important clade of cyanobacteria features fundamentally different regulatory systems to those of most prokaryotes. These include the interaction with small proteins, the so-called inactivating factors (IFs) that inhibit GS linearly with their abundance. In addition to this protein interaction-based regulation of GS activity, cyanobacteria use alternative elements to control the synthesis of GS and IFs at the transcriptional level. Moreover, cyanobacteria evolved unique RNA-based regulatory mechanisms such as glutamine riboswitches to tightly tune IF abundance. In this review, we aim to outline the current knowledge on the distinctive features of the cyanobacterial GS encompassing the overall control of its activity, sensing the nitrogen status, transcriptional and post-transcriptional regulation, as well as strain-specific differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.