Evidence map›Paper›PMID 30373232›Full record

ArticleMolecules (Basel, Switzerland)2018

A Novel Lipopeptaibol Emericellipsin A with Antimicrobial and Antitumor Activity Produced by the Extremophilic Fungus

Eugene A Rogozhin, Vera S Sadykova, Anna A Baranova, Alexey S Vasilchenko, Vladislav A Lushpa, Konstantin S Mineev, Marina L Georgieva, Alexander B Kul'ko, Mikhail E Krasheninnikov, Alexey V Lyundup and 2 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Structure-activity correlations for peptaibols obtained from clade Longibrachiatum ofComputational and structural biotechnology journal · 2023
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Antibacterial activity of peptaibols fromFrontiers in microbiology · 2022
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. The Emericellipsins A-E from an Alkalophilic FungusJournal of fungi (Basel, Switzerland) · 2021
    Article
  20. Nigellothionins from Black Cumin (Antibiotics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eugene A RogozhinShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia. rea21@list.ru.ORCID 0000-0003-0659-9547
Vera S SadykovaGause Institute of New Antibiotics, ul. Bolshaya Pirogovskaya, 11, Moscow 119021, Russia. sadykova_09@mail.ru.
Anna A BaranovaGause Institute of New Antibiotics, ul. Bolshaya Pirogovskaya, 11, Moscow 119021, Russia. anjabaranowa@list.ru.
Alexey S VasilchenkoTyumen State University, 6 Volodarskogo str, Tyumen 625003, Russia. avasilchenko@gmail.com.ORCID 0000-0001-9970-4881
Vladislav A LushpaShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia. lushpa@phystech.edu.
Konstantin S MineevShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia. konstantin.mineev@gmail.com.ORCID 0000-0002-2418-9421
Marina L GeorgievaGause Institute of New Antibiotics, ul. Bolshaya Pirogovskaya, 11, Moscow 119021, Russia. i-marina@yandex.ru.
Alexander B Kul'koMoscow Government Health Department Scientific and Clinical Antituberculosis Center, ul. Stromynka, 10, Moscow 107014, Russia. kulko-fungi@yandex.ru.
Mikhail E KrasheninnikovInstitute of Molecular Medicine, Advanced Cell Technologies Department, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Trubetskaya St. 8, Bldg. 2, Moscow 119991, Russia. krashen@rambler.ru.ORCID 0000-0002-3574-4013
Alexey V LyundupInstitute of Molecular Medicine, Advanced Cell Technologies Department, Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, Trubetskaya St. 8, Bldg. 2, Moscow 119991, Russia. lyundup@gmail.com.
Anastasia V VasilchenkoTyumen State University, 6 Volodarskogo str, Tyumen 625003, Russia. vasilchenko.av.83@gmail.com.
Yaroslav A AndreevShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia. shifter2007@gmail.com.

Funding

Russian Ministry of Education and Science grant RFMEFI62117X0018Russian Science Foundation 16-15-00167
6 · The paper itself

Abstract

Soil fungi are known to contain a rich variety of defense metabolites that allow them to compete with other organisms (fungi, bacteria, nematodes, and insects) and help them occupy more preferential areas at the expense of effective antagonism. These compounds possess antibiotic activity towards a wide range of other microbes, particularly fungi that belong to different taxonomical units. These compounds include peptaibols, which are non-ribosomal synthesized polypeptides containing non-standard amino acid residues (alpha-aminoisobutyric acid mandatory) and some posttranslational modifications. We isolated a novel antibiotic peptide from the culture medium of

Indexed as

Anti-Infective AgentsAntineoplastic AgentsAscomycotaBacteriaCell Line, TumorCell SurvivalChromatography, High Pressure LiquidFungiHumansMagnetic Resonance SpectroscopyMass SpectrometryMicrobial Sensitivity TestsMolecular StructureAnti-Infective AgentsAntineoplastic Agents2D structureantibacterial activityantifungal activitycytotoxic propertiesemericellipsin AEmericellopsis alkalinaPeptaibol

Identifiers

PMID30373232
PMCPMC6278523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.