Evidence map›Paper›PMID 30373146›Full record

ReviewInternational journal of molecular sciences2018

The Pathophysiology of Gestational Diabetes Mellitus.

Jasmine F Plows, Joanna L Stanley, Philip N Baker, Clare M Reynolds, Mark H Vickers

4 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 907 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
907citing papers in PubMed, 13 pooled it
76.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03964987 completednot on this map

PDX-1 and NGN-3 Expression in Gestational Diabetes

Typeobservational_patient_registrySponsorMaterno-Perinatal Hospital of the State of MexicoRan2018 to 2018Enrolled48ConditionsGestational Diabetes
NCT04769375 completednot on this mapstarted 2021, after this paper: background citation

Investigation of the Effect of Gestational Diabetes Mellitus on the Pelvic Girdle Pain and Symptom Severity in Pregnant Women

Typeobservational_patient_registrySponsorSultan Abdulhamid Han Training and Research Hospital, Istanbul, TurkeyRan2021 to 2021Enrolled200ConditionsGestational Diabetes, Pelvic Girdle Pain, Pregnant WomanArmsEvaluation of pain, Application of pelvic girdle pain tests, Application of pelvic girdle questionnaire
NCT05403437 completednot on this mapstarted 2022, after this paper: background citation

Investigation of the Effect of Gestational Diabetes Mellitus on Pelvic Girdle Pain Symptom Severity

TypeobservationalSponsorSultan Abdulhamid Han Training and Research Hospital, Istanbul, TurkeyRan2022 to 2025Enrolled155ConditionsPregnant Women, Gestational Diabetes, Pelvic Girdle PainArmsEvaluation of pain, Evaluation of pelvic girdle pain diagnostic tests, Evaluation of activity limitation
NCT07682077 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of a Kefir Intervention in Pregnancy on Glucose, Insulin, Gestational Diabetes Mellitus, and the Gut Microbiome and Metabolites: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of New BrunswickRan2026 to 2029Enrolled60ConditionsGestational Diabetes Mellitus (GDM), Blood Glucose, Insulin Resistance, Diabetes, Gut MicrobiomeArmsKefir
3 · Its place in the literature

Who cites it

907 citing papers in PubMed, 13 syntheses or guidelines pooled it, 1,676 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Metformin + Insulin vs. Insulin for GDM and T2DM during pregnancy: systematic review and meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026 · on this map
    Pooled it
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  11. Association ofBiomolecules & biomedicine · 2025
    Pooled it
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  14. Trial
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  16. Review
  17. Metformin Inhibits Trophoblast Ferroptosis by Suppressing ATF2 and Activating the PI3K/Akt/Nrf2 Pathway to Improve Gestational Diabetes Mellitus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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847 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Jasmine F PlowsDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA. plows@usc.edu.ORCID 0000-0002-1421-3387
Joanna L StanleyLiggins Institute, University of Auckland, Auckland 1023, New Zealand. jostnly@gmail.com.
Philip N BakerUniversity of Leicester, University Road, Leicester LE1 7RH, UK. philip.baker@leicester.ac.uk.
Clare M ReynoldsLiggins Institute, University of Auckland, Auckland 1023, New Zealand. c.reynolds@auckland.ac.nz.
Mark H VickersLiggins Institute, University of Auckland, Auckland 1023, New Zealand. m.vickers@auckland.ac.nz.ORCID 0000-0003-4876-9356
University of Auckland · NZUniversity of Leicester · GBUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation. In most cases, this hyperglycemia is the result of impaired glucose tolerance due to pancreatic β-cell dysfunction on a background of chronic insulin resistance. Risk factors for GDM include overweight and obesity, advanced maternal age, and a family history or any form of diabetes. Consequences of GDM include increased risk of maternal cardiovascular disease and type 2 diabetes and macrosomia and birth complications in the infant. There is also a longer-term risk of obesity, type 2 diabetes, and cardiovascular disease in the child. GDM affects approximately 16.5% of pregnancies worldwide, and this number is set to increase with the escalating obesity epidemic. While several management strategies exist-including insulin and lifestyle interventions-there is not yet a cure or an efficacious prevention strategy. One reason for this is that the molecular mechanisms underlying GDM are poorly defined. This review discusses what is known about the pathophysiology of GDM, and where there are gaps in the literature that warrant further exploration.

Indexed as

AdiponectinAdipose TissueAnimalsDiabetes, GestationalFemaleGlucoseHumansInsulin ResistanceInsulin-Secreting CellsLeptinOxidative StressPregnancyRisk FactorsAdiponectinGlucoseLeptingestational diabetesmolecularpathologypathophysiologyphysiologypregnancy

Identifiers

PMID30373146
PMCPMC6274679
OpenAlexW2898266729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.