Evidence map›Paper›PMID 30372798›Full record

ReviewInternational journal of clinical practice2019

An appraisal of emergency medicine clinical practice guidelines: Do we agree?

Alyssa Zupon, Craig Rothenberg, Katherine Couturier, Ting-Xu Tan, Gina Siddiqui, Matthew James, Dan Savage, Edward R Melnick, Arjun K Venkatesh

Abstract readReview
In one paragraph

Review in International journal of clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alyssa ZuponYale University School of Medicine, New Haven, Connecticut.
Craig RothenbergDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut.ORCID http://orcid.org/0000-0003-3594-600X
Katherine CouturierDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut.
Ting-Xu TanDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut.
Gina SiddiquiDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut.
Matthew JamesDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut.
Dan SavageDepartment of Emergency Medicine, University of California, San Francisco (UCSF) Fresno Medical Education Program, San Francisco, California.
Edward R MelnickDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut.
Arjun K VenkateshDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut.

Funding

Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Yale University Clinical and Translational Science Award ProgramKL2TR000140 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$2.9M
Emergency Medicine Foundation Health Policy Scholar AwardNational Center for Advancing Translational Sciences KL2 TR000140NCATS NIH HHS KL2 TR000140NCATS NIH HHS KL2 TR001862
6 · The paper itself

Abstract

backgroundClinical practice guidelines (CPGs) have been published by the American College of Emergency Physicians (ACEP) since 1990 to advance evidence-based emergency care. ACEP clinical policies have drawn anecdotal criticism for bias, yet the overall quality of these guidelines has not previously been quantified. We sought to examine ACEP clinical policies using a recognised, validated appraisal instrument: Appraisal of Guidelines for Research & Evaluation (AGREE II).

methodsSystematic assessment of current ACEP clinical policies was conducted using the AGREE II instrument, which contains 23 appraisal items (scored on a 1-7 scale) in six domains and two overall assessments. Each policy was independently appraised by five trained appraisers. Primary outcomes were AGREE II ratings for each item, domain and "Overall Assessment," and scores were reported as standardised percentages from all five appraisers. Secondary analyses examined associations between AGREE II ratings and policy publication date, strength of underlying evidence and strength of recommendations. Additional analysis examined relationships between domain and "Overall Assessment" ratings.

resultsTwenty guidelines published from April 2007 to November 2017 were included. Of the six domains, "Scope and Purpose" scored highest (mean 90%) and "Applicability" scored lowest (mean 35%). The four remaining domains ("Stakeholder Involvement," "Rigor of Development," "Clarity of Presentation" and "Editorial Independence") had mean scores of 53%-78%. The mean "Overall Assessment" rating was 69% and was not associated with policy publication date, strength of underlying evidence or strength of recommendations. We found positive associations between "Overall Assessment" ratings and two domains: "Rigor of Development" (r = 0.70) and "Clarity of Presentation" (r = 0.70).

conclusionsBased on validated AGREE II criteria, ACEP clinical policies can be most improved by addressing their application in practice. ACEP clinical policies' overall quality did not improve over the assessed time period and is not explained by the quality of underlying evidence.

Indexed as

Emergency MedicineEvidence-Based MedicineHumansPractice Guidelines as Topic

Identifiers

PMID30372798
PMCPMC6351191

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.