Evidence map›Paper›PMID 30372704›Full record

ArticleObesity facts2018

Plasma Oxytocin Concentration in Pre- and Postmenopausal Women: Its Relationship with Obesity, Body Composition and Metabolic Variables.

Sabrina Maestrini, Chiara Mele, Stefania Mai, Roberta Vietti, Annamaria Di Blasio, Luigi Castello, Daniela Surico, Gianluca Aimaretti, Massimo Scacchi, Paolo Marzullo

Open access · goldAbstract read
In one paragraph

Article in Obesity facts, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Role of Oxytocin in Obesity.Current diabetes reports · 2026
    Review
  4. Article
  5. The serum oxytocin correlated with serum leptin and body mass index in Japanese adolescents.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Oxytocin and women's health in midlife.The Journal of endocrinology · 2024
    Review
  10. Review
  11. The Effect of Oxytocin on Osteoporosis Improvement: A Systematic Review.Medical journal of the Islamic Republic of Iran · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Oxytocin in Women's Health and Disease.Frontiers in endocrinology · 2022
    Review
  17. Oxytocin and Bone: Review and Perspectives.International journal of molecular sciences · 2021
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sabrina Maestrini
Chiara Mele
Stefania Mai
Roberta Vietti
Annamaria Di Blasio
Luigi Castello
Daniela Surico
Gianluca Aimaretti
Massimo Scacchi
Paolo Marzullo
IRCCS Istituto Auxologico Italiano · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITOspedale San Giuseppe · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the relationship between oxytocin, menopause and obesity.

methodsA cross-sectional analysis on 56 obese (OB; 28 premenopausal) and 53 normal-weight women (NW; 27 premenopausal) was performed by measurement of oxytocin, leptin, adiponectin, gonadotropins, sex steroids, glucose, and lipid homeostasis as well as DXA assessment of fat mass (%FM) and fat-free mass (FFM).

resultsWomen from NW and OB groups were comparable for age but differed in anthropometric measures. In our cohorts, menopause was not associated with changes in gluco-lipid homeostasis and %FM, while FFM was lower in postmenopausal women from both study groups (p < 0.05). In each group, leptin was unaltered, and adiponectin only marginally changed across menopause, while oxytocin levels were lower in post- than in premenopausal women (NW: p < 0.05; OB: p < 0.005), and lower in OB than NW women, either when assessed as whole groups or if stratified by menopause (p < 0.001). In correlation analysis, inverse associations related oxytocin to menopause, obesity, and adiposity-related measures. BMI (p < 0.0001) and menopause independently predicted oxytocin levels (p < 0.001), but their interaction was null (p = 0.5).

conclusionsObesity and menopause are independent negative predictors of plasma oxytocin. Longitudinal studies should clarify the role of oxytocin on weight modifications experienced around and after menopause.

Indexed as

AdiposityAdultBody CompositionCross-Sectional StudiesEnergy MetabolismFemaleHumansLeptinMenopauseMiddle AgedObesityOxytocinPostmenopausePremenopauseLeptinOxytocinBody compositionMenopauseObesityOxytocin

Identifiers

PMID30372704
PMCPMC6257199
OpenAlexW2898729053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.