Evidence map›Paper›PMID 30372680›Full record

Trial reportJournal of Alzheimer's disease : JAD2019

A Randomized Controlled Trial of Adherence to a 24-Month Home-Based Physical Activity Program and the Health Benefits for Older Adults at Risk of Alzheimer's Disease: The AIBL Active-Study.

Kay L Cox, Elizabeth V Cyarto, Kathryn A Ellis, David Ames, Patricia Desmond, Pramit Phal, Matthew J Sharman, Cassandra Szoeke, Christopher C Rowe, Colin L Masters and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  11. Profiles of lifestyle health behaviors and cognitive decline in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kay L CoxMedical School University of Western Australia, Perth, Australia.
Elizabeth V CyartoBolton Clarke Research Institute, Melbourne, Australia.
Kathryn A EllisAcademic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
David AmesAcademic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Patricia DesmondDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Australia.
Pramit PhalDepartment of Radiology, Royal Melbourne Hospital, University of Melbourne, Australia.
Matthew J SharmanSchool of Health Sciences, University of Tasmania, Launceston, Tasmania, Australia.
Cassandra SzoekeDepartment of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, Australia.
Christopher C RoweDepartment of Molecular Imaging & Therapy, Austin Health, Melbourne, Australia.
Colin L MastersThe Florey Institute, The University of Melbourne, Australia.
Emily YouAcademic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Sally BurrowsMedical School University of Western Australia, Perth, Australia.
Michelle M Y LaiAcademic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Nicola T LautenschlagerAcademic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have demonstrated that physical activity (PA) interventions can improve physical and cognitive outcomes in older adults, but most have been relatively short in duration (<1 year) with a few having specifically targeting individuals at risk of developing Alzheimer's disease.

objectiveTo examine adherence and physical health outcomes in a 24-month home-based PA intervention in older adults at risk of Alzheimer's disease.

methodsParticipants 60 years and older with mild cognitive impairment (MCI) or subjective memory complaints (SMC) with at least 1 cerebrovascular risk factor recruited from The Australian Imaging Biomarkers and Lifestyle Flagship Study of Aging (AIBL) were randomized to a PA or control group (n = 106). The control group continued with their usual lifestyle. The PA group received a 24-month home-based program with a target of 150 minutes/week of moderate PA and a behavioral intervention. Retention (participants remaining) and PA adherence (PA group only, percent PA completed to the PA prescribed) were determined at 6, 12, 18, and 24 months. Assessments at baseline, 6, 12, and 24 months included, PA; fitness; body composition and fat distribution. Key outcome measures were PA adherence and PA.

resultsThe 24-month retention rate (97.2%) and the median PA adherence 91.67% (Q1-Q3, 81.96, 100.00) were excellent. In the long-term the intervention group achieved significantly better improvements in PA levels, leg strength, fat mass and fat distribution compared to the control.

conclusionThis study demonstrates that in this target group, long-term PA adherence is achievable and has physical health benefits.

Indexed as

Life StylePatient ComplianceAgedAgingAlzheimer DiseaseCognitive DysfunctionExerciseFemaleHumansMaleMiddle AgedAdherencecerebrovascular diseasemild cognitive impairmentphysical activitysubjective memory complaints

Identifiers

PMID30372680
PMCPMC6700652

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.