Evidence map›Paper›PMID 30372661›Full record

ArticleActa orthopaedica2018

Blood cytokine pattern and clinical outcome in knee arthroplasty patients: comparative analysis 5 years after standard versus "hypoallergenic" surface coated prosthesis implantation.

Peter Thomas, Philipp Hisgen, Hartmuth Kiefer, Ulf Schmerwitz, Andreas Ottersbach, Dominique Albrecht, Burkhard Summer, Christian Schinkel

Abstract readComparative StudyMulticenter StudyVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta orthopaedica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Increased inflammatory response is associated with less favorable functional results 5 years after total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023
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  15. Return to physical activity and change in body mass index after hypoallergenic medial mobile-bearing unicompartmental knee arthroplasty.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter Thomasa Department of Dermatology and Allergology , Ludwig-Maximilians-University , Munich , Germany ;
Philipp Hisgenb Department of Trauma Surgery and Orthopaedics , Klinikum Memmingen, Germany (Academic Teaching Hospital of Ludwig-Maximilians-University Munich) ;
Hartmuth Kieferc Clinic of Trauma Surgery and Orthopaedics , Bünde , Germany ;
Ulf Schmerwitzc Clinic of Trauma Surgery and Orthopaedics , Bünde , Germany ;
Andreas Ottersbachd Clinic for Orthopaedic Surgery , Brig , Switzerland ;
Dominique Albrechtd Clinic for Orthopaedic Surgery , Brig , Switzerland ;
Burkhard Summera Department of Dermatology and Allergology , Ludwig-Maximilians-University , Munich , Germany ;
Christian Schinkelb Department of Trauma Surgery and Orthopaedics , Klinikum Memmingen, Germany (Academic Teaching Hospital of Ludwig-Maximilians-University Munich) ;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose - Metal sensitivity might provoke complications after arthroplasty. Correspondingly, coated "hypoallergenic" implants are of interest but long-term follow-up data are missing. Thus, we assessed immunological and clinical parameters in such patients. Patients and methods - 5 years' follow-up data were obtained from 3 centers, which used either a standard total knee replacement (TKR) or the identical implant with multilayer surface zirconium nitride based coating. Of the 196 patients (mean age 68 years (44-84), 110 females) 97 had arthroplasty with a coated surface, and 99 were treated by a standard TKR of the same type. Investigations were Knee Society Score (KSS), Knee injury and Osteoarthritis Outcome Score (KOOS), radiographic analysis, and cytokine measurement in peripheral blood. Pro- and anti-inflammatory cytokines were evaluated by cytometric beads assay and RT-PCR. Results - Survival rate (Kaplan-Meier) was 98% for coated and 97% for uncoated implants after 5 years. Mechanical axis and KSS pain score (42 vs. 41 (0-50)) were comparable. Most serum cytokine levels were comparable, but mean interleukin-8 and interleukin-10 levels were higher in the group with an uncoated implant. IL-8: 37 (SD 7.5) pg/mL vs. 1.1 (SD 4.3) (p < 0.001); IL-10: 3.6 (SD 2.5) vs. 0.3 (SD 1.8) pg/mL (p < 0.001). Interpretation - There was similar clinical outcome 5 years after standard and surface-coated TKR. In peripheral blood there was an increased pro-inflammatory status, i.e., significant elevation of IL-8 and the anti-inflammatory IL-10, after standard uncoated prosthesis. Any long-term effects of these cytokine changes are unknown.

Indexed as

Arthroplasty, Replacement, KneeKnee ProsthesisProsthesis DesignAdultAgedAged, 80 and overCoated Materials, BiocompatibleCytokinesDermatitis, Allergic ContactFemaleHumansKaplan-Meier EstimateMaleMiddle AgedOsteoarthritis, KneeZirconiumCoated Materials, BiocompatibleCytokinesZirconiumzirconium nitride

Identifiers

PMID30372661
PMCPMC6300722

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.