ArticleDevelopmental science2019
Altered lateralization of dorsal language tracts in 6-week-old infants at risk for autism.
Article in Developmental science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses.Autism research : official journal of the International Society for Autism Research · 2026Pooled it
- Presymptomatic Biological, Structural, and Functional Diagnostic Biomarkers of Autism Spectrum Disorder.Journal of neurochemistry · 2025Pooled it
- Neural correlates and predictors of speech and language development in infants at elevated likelihood for autism: a systematic review.Frontiers in human neuroscience · 2023Pooled it
- Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- The Value of Brain Imaging and Electrophysiological Testing for Early Screening of Autism Spectrum Disorder: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Alterations in Early Alpha-band Connectivity emerge in Infancy among children later diagnosed with Autism.medRxiv : the preprint server for health sciences · 2026Article
- Study on the Topological Properties of Language Brain Region Networks in Children With Autism Based on Diffusion Tensor Imaging (DTI).Journal of autism and developmental disorders · 2026Article
- Deciphering multiway multiscale brain network connectivity from birth to 6 months.Communications biology · 2026Article
- The Development of Lateralized Brain Oscillations in Infants: Lessons From Autism.Developmental psychobiology · 2025Article
- Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism.Molecular autism · 2025Article
- Methodological considerations on diffusion MRI tractography in infants aged 0-2 years: a scoping review.Pediatric research · 2025Article
- Deciphering Multiway Multiscale Brain Network Connectivity: Insights from Birth to 6 Months.bioRxiv : the preprint server for biology · 2025Article
- Sensory-movement underpinnings of lifelong neurodivergence: getting a grip on autism.Frontiers in integrative neuroscience · 2025Article
- Altered white matter connectivity is linked to language abilities in children with autism spectrum disorder: An automated fiber quantification study.Frontiers in psychiatry · 2025Article
- Atypical Neural Responses to Native and Non-Native Language in Infants at High Likelihood for Developing Autism.Research square · 2024Article
- White matter development and language abilities during infancy in autism spectrum disorder.Molecular psychiatry · 2024Article
- Atypical functional connectivity between the amygdala and visual, salience regions in infants with genetic liability for autism.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Bridging the Divide: Brain and Behavior in Developmental Language Disorder.Brain sciences · 2023Review
- Lateralization of major white matter tracts during infancy is time-varying and tract-specific.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Visual Global Processing and Subsequent Verbal and Non-Verbal Development: An EEG Study of Infants at Elevated versus Low Likelihood for Autism Spectrum Disorder.Journal of autism and developmental disorders · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Altered structural connectivity has been identified as a possible biomarker of autism spectrum disorder (ASD) risk in the developing brain. Core features of ASD include impaired social communication and early language delay. Thus, examining white matter tracts associated with language may lend further insight into early signs of ASD risk and the mechanisms that underlie language impairments associated with the disorder. Evidence of altered structural connectivity has previously been detected in 6-month-old infants at high familial risk for developing ASD. However, as language processing begins in utero, differences in structural connectivity between language regions may be present in the early infant brain shortly after birth. Here we investigated key white matter pathways of the dorsal language network in 6-week-old infants at high (HR) and low (LR) risk for ASD to identify atypicalities in structural connectivity that may predict altered developmental trajectories prior to overt language delays and the onset of ASD symptomatology. Compared to HR infants, LR infants showed higher fractional anisotropy (FA) in the left superior longitudinal fasciculus (SLF); in contrast, in the right SLF, HR infants showed higher FA than LR infants. Additionally, HR infants showed more rightward lateralization of the SLF. Across both groups, measures of FA and lateralization of these pathways at 6 weeks of age were related to later language development at 18 months of age as well as ASD symptomatology at 36 months of age. These findings indicate that early differences in the structure of language pathways may provide an early predictor of future language development and ASD risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.