ArticleScandinavian journal of medicine & science in sports2019
Impairment of left atrial mechanics does not contribute to the reduction in stroke volume after active ascent to 4559 m.
Article in Scandinavian journal of medicine & science in sports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Change in pulmonary artery pressure upon acute exposure to high altitude: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Right Ventricular Response to Acute Hypoxia Exposure: A Systematic Review.Frontiers in physiology · 2021Pooled it
- Association between baseline blood pressure variability and cardiac mechanics and electrophysiology after acute exposure to high altitude.BMC cardiovascular disorders · 2026Article
- Altitude exposure in pediatric pulmonary hypertension-are we ready for (flight) recommendations?Cardiovascular diagnosis and therapy · 2021Review
- Atrial performance in healthy subjects following high altitude exposure at 4100 m: 2D speckle-tracking strain analysis.The international journal of cardiovascular imaging · 2021Article
- Habitation Altitude and Left Ventricular Diastolic Function: A Population-Based Study.Journal of the American Heart Association · 2021Article
- Preserved right ventricular function but increased right atrial contractile demand in altitude-induced pulmonary hypertension.The international journal of cardiovascular imaging · 2020Article
- Impairment of left atrial mechanics does not contribute to the reduction in stroke volume after active ascent to 4559 m.Scandinavian journal of medicine & science in sports · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia challenges left ventricular (LV) function due to reduced energy supply. Conflicting results exist whether high-altitude exposure impairs LV diastolic function and thus contributes to the high altitude-induced increase in systolic pulmonary artery pressure (sPAP) and reduction in stroke volume (SV). This study aimed to assess LV diastolic function, LV end-diastolic pressure (LVEDP), and LA mechanics using comprehensive echocardiographic imaging in healthy volunteers at 4559 m. Fifty subjects performed rapid (<20 hours) and active ascent from 1130 m to 4559 m (high). All participants underwent echocardiography during baseline examination at 424 m (low) as well as 7, 20 and 44 hours after arrival at high altitude. Heart rate (HR), sPAP, and comprehensive volumetric- and Doppler- as well as speckle tracking-derived LA strain parameters were obtained to assess LV diastolic function, LA mechanics, and LVEDP in a multiparametric approach. Data for final analyses were available in 46 subjects. HR (low: 64 ± 11 vs high: 79 ± 14 beats/min, P < 0.001) and sPAP (low: 24.4 ± 3.8 vs high: 38.5 ± 8.2 mm Hg, P < 0.001) increased following ascent and remained elevated at high altitude. Stroke volume (low: 64.5 ± 15.0 vs high: 58.1 ± 16.4 mL, P < 0.001) and EDV decreased following ascent and remained decreased at high altitude due to decreased LV passive filling volume, whereas LA mechanics were preserved. There was no case of LV diastolic dysfunction or increased LVEDP estimates. In summary, this study shows that rapid and active ascent of healthy individuals to 4559 m impairs passive filling and SV of the LV. These alterations were not related to changes in LV and LA mechanics.
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Registered trials
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