ArticleClinical transplantation2018
Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.
Article in Clinical transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Urinary microbiome in renal transplant patients with BK polyomavirus reactivation.Journal of medical microbiology · 2026Article
- Kidney Transplantation and the Gut-Kidney Axis: Microbial, Metabolic, and Nutritional Implications for Graft and Patient Outcomes.Nutrients · 2026Review
- Urobiome composition after renal transplantation: an exploratory study.BMC microbiology · 2026Article
- Urinary Microbiome Characteristics in Kidney Transplant Recipients and Their Clinical Implications: A Narrative Review.Annals of transplantation · 2026Review
- Fungal Infections in Kidney Transplant Recipients: A Comprehensive Narrative Review.Microorganisms · 2025Review
- Dysbiosis in Human Urinary Microbiota May Differentiate Patients with a Bladder Cancer.International journal of molecular sciences · 2024Article
- The Role of the Urobiome in Kidney Transplantation: A Systematic Review.Transplantation direct · 2024Article
- Application of Various Techniques to Gain Insights Into the Complex Urinary Tract Microbial Communities of Renal Transplant Recipients.Transplantation direct · 2023Article
- Differences in the composition of the bacterial element of the urinary tract microbiome in patients undergoing dialysis and patients after kidney transplantation.Frontiers in microbiology · 2023Article
- Urine microbiome in individuals with an impaired immune system.Frontiers in cellular and infection microbiology · 2023Review
- Impact of donor multidrug-resistant organisms on solid organ transplant recipient outcomes.Transplant infectious disease : an official journal of the Transplantation Society · 2022Article
- Determination of the Optimal Bacterial DNA Extraction Method to Explore the Urinary Microbiota.International journal of molecular sciences · 2022Article
- Mechanisms of Zhenwu decoction for the treatment of renal fibrosis at various stages: What is the role ofFrontiers in microbiology · 2022Article
- The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation.Frontiers in immunology · 2022Review
- Accessing Dietary Effects on the Rumen Microbiome: Different Sequencing Methods Tell Different Stories.Veterinary sciences · 2021Article
- Causes of Renal Allograft Injury in Recipients With Normal Donor-derived Cell-free DNA.Transplantation direct · 2021Article
- The Human Microbiome in Chronic Kidney Disease: A Double-Edged Sword.Frontiers in medicine · 2021Review
- Urinary Microbiome: Yin and Yang of the Urinary Tract.Frontiers in cellular and infection microbiology · 2021Review
- Urinary Microbiota-Are We Ready for Prime Time? A Literature Review of Study Methods' Critical Steps in Avoiding Contamination and Minimizing Biased Results.Diagnostics (Basel, Switzerland) · 2020Review
- Does the Microbiome Affect the Outcome of Renal Transplantation?Frontiers in cellular and infection microbiology · 2020Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe performed a study to identify differences in the urinary microbiome associated with chronic allograft dysfunction (CAD) and compared the urinary microbiome of male and female transplant recipients with CAD.
methodsThis case-control study enrolled 67 patients within the Deterioration of Kidney Allograft Function (DeKAF) Genomics cohort at two transplant centers. CAD was defined as a greater than 25% rise in serum creatinine relative to a 3 month post-transplant baseline. Urine samples from patients with and without CAD were analyzed using 16S V4 bacterial ribosomal DNA sequences.
resultsCorynebacterium was more prevalent in female and male patients with CAD compared to non-CAD female patients (P = 0.0005). A total 21 distinct Operational Taxonomic Unit (OTUs) were identified as significantly different when comparing CAD and non-CAD patients using Kruskal-Wallis (P < 0.01). A subset analysis of female patients with CAD compared to non-CAD females identified similar differentially abundant OTUs, including the genera Corynebacterium and Staphylococcus (Kruskal-Wallis; P = 0.01; P = 0.004, respectively). Male CAD vs female CAD analysis showed greater abundance of phylum Proteobacteria in males.
conclusionThere were differences in the urinary microbiome when comparing female and male CAD patients with their female non-CAD counterparts and these differences persisted in the subset analysis limited to female patients only.
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