ArticlePloS one2018
No change in plasma tau and serum neurofilament light concentrations in adolescent athletes following sport-related concussion.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Ultrasensitive assays for detection of plasma tau and phosphorylated tau 181 in Alzheimer's disease: a systematic review and meta-analysis.Translational neurodegeneration · 2021Pooled it
- Mapping the acute trajectory of sport-related concussion outcomes across symptoms, cognition, and blood biomarkers.Sports medicine and health science · 2026Review
- Sport-Related Concussions in High School Athletes: A Comprehensive Update.Current neurology and neuroscience reports · 2025Review
- The neuropathological basis of elevated serum neurofilament light following experimental concussion.Acta neuropathologica communications · 2024Article
- Plasma Biomarkers of Traumatic Brain Injury in Adolescents With Sport-Related Concussion.JAMA network open · 2024Article
- The Potential Role of Neurofilament Light in Mild Traumatic Brain Injury Diagnosis: A Systematic Review.Cureus · 2022Review
- Traumatic Brain Injury Biomarkers, Simulations and Kinetics.Bioengineering (Basel, Switzerland) · 2022Article
- Serum neurofilament light in professional soccer players: goal on safety.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Repeated Sub-Concussive Impacts and the Negative Effects of Contact Sports on Cognition and Brain Integrity.International journal of environmental research and public health · 2022Review
- The biological significance and clinical utility of emerging blood biomarkers for traumatic brain injury.Neuroscience and biobehavioral reviews · 2021Review
- Blood biomarkers for mild traumatic brain injury: a selective review of unresolved issues.Biomarker research · 2021Review
- A population-based study of head injury, cognitive function and pathological markers.Annals of clinical and translational neurology · 2021Article
- Prolonged elevation of serum neurofilament light after concussion in male Australian football players.Biomarker research · 2021Article
- Plasma Biomarker Concentrations Associated With Return to Sport Following Sport-Related Concussion in Collegiate Athletes-A Concussion Assessment, Research, and Education (CARE) Consortium Study.JAMA network open · 2020Article
- Serum Protein Biomarker Findings Reflective of Oxidative Stress and Vascular Abnormalities in Male, but Not Female, Collision Sport Athletes.Frontiers in neurology · 2020Article
- Assessment of Long-Term Effects of Sports-Related Concussions: Biological Mechanisms and Exosomal Biomarkers.Frontiers in neuroscience · 2020Review
- Neurofilament Light Chain as a Biomarker in Multiple Sclerosis.Frontiers in neurology · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Sport-related concussion (SRC), a mild form of traumatic brain injury (TBI), is a common injury in contact sports. Health care professionals rely on subjective criteria (e.g., symptoms), as there is no objective marker for identification of athletes with SRC. Blood-based biomarkers have shown promise as diagnostic and prognostic tools following TBI and SRC. In the present study, we examined plasma tau and serum NF-L, two biomarkers for neuronal/axonal injury, concentrations at preseason and following SRC in contact sport athletes (n = 11) using ultrasensitive single molecule array (Simoa) assays. Preseason baseline samples were collected, and post-concussion samples were obtained at 6- and 14-days following injury. We found no difference between baseline, 6-day and 14-day post-concussion concentrations of tau (p = 0.14) or NF-L (p = 0.53). Further, no difference was found between preseason baseline and all post-SRC samples for tau (p = 0.22) or NF-L (p = 0.98). The total number of symptoms reported on the Standardized Assessment of Concussion- 3rd Edition (SCAT3) and associated symptom severity scores increased from preseason to 6-days post-SRC but returned to baseline values at 14-days (p = 0.02 and p = 0.003, respectively). These results suggest that the severity of neuronal injury in this cohort of contact sport athletes with clinical uncomplicated SRC was too low to be detected by tau and NF-L measurements in blood samples obtained at 6- and 14-days post-injury.
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Registered trials
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