ArticlePloS one2018
Engineering electrospun multicomponent polyurethane scaffolding platform comprising grapeseed oil and honey/propolis for bone tissue regeneration.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Sustainable hemocompatibility prediction of electrospun nanomaterials using SEM-driven CNN ensemble learning aligned with ISO 10993.PloS one · 2026Article
- A Comparison of Ester- and Ether-Based Bio-TPUs With Regard to Their Resistance to Environmental Influences in Terms of Their Mechanical and Adhesive Properties.Biopolymers · 2025Article
- Synthesis and characterization of 3D gelatin/calcium hydroxide/dentin matrix proteins/propolis scaffolds for hard tissue engineering.BMC oral health · 2025Article
- Medical Benefits and Polymer Applications of Grapes.Polymers · 2025Review
- The effect of green synthesis of TiOVeterinary medicine and science · 2023Article
- Emerging applications of 3D engineered constructs from plant seed extracts.Turkish journal of biology = Turk biyoloji dergisi · 2023Article
- Nanomaterials Based on Honey and Propolis for Wound Healing-A Mini-Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Development and Characterizations of Engineered Electrospun Bio-Based Polyurethane Containing Essential Oils.Membranes · 2022Article
- Essential Oils for Bone Repair and Regeneration-Mechanisms and Applications.Materials (Basel, Switzerland) · 2021Review
- Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering.Materials (Basel, Switzerland) · 2020Article
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Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential oils play an important role in reducing the pain and inflammation caused by bone fracture.In this study, a scaffold was electrospun based on polyurethane (PU), grape seed oil, honey and propolis for bone tissue-engineering applications. The fiber diameter of the electrospun PU/grape seed oil scaffold and PU/grape seed oil/honey/propolis scaffold were observed to be reduced compared to the pristine PU control. FTIR analysis revealed the existence of grape seed oil, honey and propolis in PU identified by CH band peak shift and also hydrogen bond formation. The contact angle of PU/grape seed oil scaffold was found to increase owing to hydrophobic nature and the contact angle for the PU/grape seed/honey oil/propolis scaffold were decreased because of hydrophilic nature. Further, the prepared PU/grape seed oil and PU/grape seed oil/honey/propolis scaffold showed enhanced thermal stability and reduction in surface roughness than the control as revealed in thermogravimetric analysis (TGA) and atomic force microscopy (AFM) analysis. Further, the developed nanocomposite scaffold displayed delayed blood clotting time than the pristine PU in the activated prothrombin time (APTT) and partial thromboplastin time (PT) assay. The hemolytic assay and cytocompatibility studies revealed that the electrospun PU/grape seed oil and PU/grape seed oil/honey/propolis scaffold possess non-toxic behaviour to red blood cells (RBC) and human fibroblast cells (HDF) cells indicating better blood compatibility and cell viability rates. Hence, the newly developed electrospun nanofibrous composite scaffold with desirable characteristics might be used as an alternative candidate for bone tissue engineering applications.
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