ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2019
Effects of trauma, economic hardship, and stress on neurocognition and everyday function in HIV.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Living With Chronic HIV Disease in the Antiretroviral Era: The Impact of Neurocognitive Impairment on Everyday Life Functions.Topics in antiviral medicinePooled it
- The effect of varenicline on mood and cognition in smokers with HIV.Psychopharmacology · 2020Trial
- Economic Empowerment Interventions on Mental Health Outcomes Among People Living with HIV in Low and Middle-Income Countries: A Systematic Literature Review.Behavioral sciences (Basel, Switzerland) · 2026Review
- Effects of HIV and Adverse Childhood Experiences on Neurocognition.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Pet Ownership is Associated with Durable Viral Suppression but Presents Healthcare Access Challenges for People with HIV.AIDS and behavior · 2026Article
- The role of premorbid cognitive performance in the neuropsychological assessment of people with HIV in South Africa.PloS one · 2026Article
- Psychosocial factors account for a proportion of the difference in cognitive performance between persons with and without HIV.AIDS (London, England) · 2025Article
- Life Course Stressors, Latent Coping Strategies, Alcohol Use, and Adherence among People with HIV.AIDS and behavior · 2025Article
- SIV-specific antibodies protect against inflammasome-driven encephalitis in untreated macaques.Cell reports · 2024Article
- Emotional health and its association with neurocognition in Hispanic and non-Hispanic White people with HIV.Journal of the International Neuropsychological Society : JINS · 2024Article
- Psychological grit moderates the relation between lifetime stressor exposure and functional outcomes among HIV-seropositive and HIV-seronegative adults.Stress and health : journal of the International Society for the Investigation of Stress · 2023Article
- A Trauma-Informed, Geospatially Aware, Just-in-Time Adaptive mHealth Intervention to Support Effective Coping Skills Among People Living With HIV in New Orleans: Development and Protocol for a Pilot Randomized Controlled Trial.JMIR research protocols · 2023Article
- Cognitive impairment in people living with HIV: consensus recommendations for a new approach.Nature reviews. Neurology · 2023Review
- The Evolution of Assessing Central Nervous System Complications in Human Immunodeficiency Virus: Where Do We Go From Here?The Journal of infectious diseases · 2023Article
- NIH Toolbox Emotion Battery Findings Among People with HIV: Normative Comparisons and Clinical Associations.Patient related outcome measures · 2023Article
- Effects of Early-Life Adversities on Neuropsychiatric and Executive Functions in HIV-Positive Adults.Journal of the International Neuropsychological Society : JINS · 2023Article
- The comorbidity of depression and neurocognitive disorder in persons with HIV infection: call for investigation and treatment.Frontiers in cellular neuroscience · 2023Article
- Cognitive performance in a South African cohort of people with HIV and comorbid major depressive disorder.Journal of neurovirology · 2022Article
- Social Consequences of the COVID-19 Pandemic. A Systematic Review.Investigacion y educacion en enfermeria · 2022Article
- Combined effects of older age and HIV disease on changes in everyday functioning over one year.Journal of neurovirology · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveThe causes of neurocognitive and everyday functioning impairment among aging people living with HIV (PLWH) are multifactorial. Exposure to stress and trauma can result in neurocognitive deficits via activation of neurological and other biological mechanisms.
methodPLWH (n = 122) and persons without HIV (n = 95), 35-65 years of age, completed four questionnaires that were used to generate a trauma, economic hardship (food insecurity and low socioeconomic status), and stress composite variable (TES). Participants also completed a comprehensive neuropsychological battery and standardized self-reports of activities of daily living (ADLs). We examined the independent and interactive effects of TES and HIV status on neurocognitive performance and ADL declines.
resultsPLWH had more traumatic events, more food insecurity, lower socioeconomic status, and higher perceived stress compared with HIV- individuals (all ps < .0001). Among PLWH, a higher composite TES score was associated with worse executive functioning (p = .02), worse learning (p = .02), worse working memory (p = .02), and more ADL declines (p < .0001), even after controlling for relevant demographic, psychiatric, substance use, and HIV disease covariates. On their own, individual TES components did not predict these outcomes. Conversely, no significant relationships were observed between TES and cognitive domains nor ADL declines among HIV- individuals.
conclusionsA composite score of trauma, economic hardship, and stress was significantly associated with worse neurocognitive performance and functional declines among PLWH. These adverse experiences may contribute to neurocognitive and daily functioning difficulties commonly observed among PLWH. Longitudinal studies are needed to elucidate the relationships between economic/psychosocial adversities and cognitive/functional outcomes over time, and examine potential mediators, such as inflammatory biomarkers. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
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