ArticleSleep2019
Sleep disruption elevates oxidative stress in parvalbumin-positive cells of the rat cerebral cortex.
Article in Sleep, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Sleep deprivation and risk for Parkinson's disease: evidence and therapeutic implications.Journal of neurology · 2025Review
- Circadian rhythms in metabolism and mental health: a reciprocal regulatory network with implications for metabolic and neuropsychiatric disorders.Current opinion in physiology · 2025Review
- Morphological and Molecular Characteristics of Perineuronal Nets in the Human Prefrontal Cortex-A Possible Link to Microcircuitry Specialization.Molecular neurobiology · 2025Article
- Sleep Deprivation Triggers Mitochondrial DNA Release in Microglia to Induce Neural Inflammation: Preventative Effect of Hydroxytyrosol Butyrate.Antioxidants (Basel, Switzerland) · 2024Article
- Effect of N-Acetylcysteine on Sleep: Impacts of Sex and Time of Day.Antioxidants (Basel, Switzerland) · 2023Article
- Nightshift work can induce oxidative DNA damage: a pilot study.BMC public health · 2023Article
- Wildfire-related smoke inhalation worsens cardiovascular risk in sleep disrupted rats.Frontiers in environmental health · 2023Article
- Chronic dietary supplementation with nicotinamide riboside reduces sleep need in the laboratory mouse.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Dynamic regulation of the extracellular matrix in reward memory processes: a question of time.Frontiers in cellular neuroscience · 2023Review
- Adolescent sleep and the foundations of prefrontal cortical development and dysfunction.Progress in neurobiology · 2022Review
- Interactions between Sleep and Emotions in Humans and Animal Models.Medicina (Kaunas, Lithuania) · 2022Review
- Editorial: Perineuronal Nets as Therapeutic Targets for the Treatment of Neuropsychiatric Disorders.Frontiers in synaptic neuroscience · 2022Article
- Sleep, Narcolepsy, and Sodium Oxybate.Current neuropharmacology · 2022Article
- The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN-Parvalbumin Interneuron Connectivity of the Cingulate Circuitries.Frontiers in cell and developmental biology · 2022Article
- Multi-Modal Regulation of Circadian Physiology by Interactive Features of Biological Clocks.Biology · 2021Review
- Short-Term Sleep Fragmentation Dysregulates Autophagy in a Brain Region-Specific Manner.Life (Basel, Switzerland) · 2021Article
- Cocaine memory reactivation induces functional adaptations within parvalbumin interneurons in the rat medial prefrontal cortex.Addiction biology · 2021Article
- Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex.Brain structure & function · 2021Article
- The Association of Oxidative Stress in the Uvular Mucosa with Obstructive Sleep Apnea Syndrome: A Clinical Study.Journal of clinical medicine · 2021Article
- An Extracellular Perspective on CNS Maturation: Perineuronal Nets and the Control of Plasticity.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We used a novel automated sleep disruption (SD) apparatus to determine the impact of SD on sleep and molecular markers of oxidative stress in parvalbumin (PV) neurons in the rat prefrontal cortex (PFC). Rats were subjected to two 6 hr SD sessions from zeitgeber time (ZT) 0 to ZT6, one by the gentle handling method and the other by an automated agitator running the length of the rat's home cage floor (a novel SD method). The same rats were later subjected to a 12 hr SD session from ZT0 to ZT12. Sleep was disrupted with both methods, although rats slept less during gentle handling than during the automated condition. Immediately after both SD sessions, rats displayed compensatory sleep characterized by elevated slow-wave activity. We measured in the prelimbic prefrontal cortex (prelimbic PFC; 6 and 12 hr SD) and orbital frontal cortex (12 hr SD) the intensity of the oxidative stress marker, 8-oxo-2'-deoxyguanosine (8-oxo-dG) as well as the staining intensity of PV and the PV cell-associated perineuronal net marker, Wisteria floribunda agglutinin (WFA). In the prelimbic PFC, 6 hr SD increased the intensity of 8-oxo-dG, PV, and WFA. After 12 hr SD, the intensity of 8-oxo-dG was elevated in all neurons. PV intensity was elevated only in neurons colabeled with 8-oxo-dG or WFA, and no changes were found in WFA intensity. We conclude that in association with SD-induced sleep drive, PV neurons in the prelimbic PFC exhibit oxidative stress.
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