ArticleJournal of analytical toxicology2018
Evaluation of Nicotine and the Components of e-Liquids Generated from e-Cigarette Aerosols.
Article in Journal of analytical toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Flavor-Toxicant Correlation in E-cigarettes: A Meta-Analysis.Chemical research in toxicology · 2020Pooled it
- Method Development and Validation of an Aerosol Sampling Technique for the Analysis of Nicotine in Electronic Cigarette Aerosols.Molecules (Basel, Switzerland) · 2024Article
- The impact of vaping ethanol-containing electronic cigarette liquids on roadside impairment investigations.Journal of analytical toxicology · 2023Article
- The history, evolution, and practice of cannabis and E-cigarette industries highlight necessary public health and public safety considerations.Journal of safety research · 2023Article
- Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens.Frontiers in pharmacology · 2023Article
- School-based preventive interventions targeting e-cigarette use among adolescents: a systematic review protocol.BMJ open · 2022Article
- Health effects of electronic cigarette (e‑cigarette) use on organ systems and its implications for public health.Wiener klinische Wochenschrift · 2021Review
- Identification of Gamma-Butyrolactone in JUUL Liquids.Journal of analytical toxicology · 2021Article
- Randomized controlled trials using electronic nicotine delivery systems as smoking cessation aids require an accurate, empirically-based understanding of the nicotine delivery profile of the products under study.Journal of public health and emergency · 2021Article
- A review of constituents identified in e-cigarette liquids and aerosols.Tobacco prevention & cessation · 2021Review
- Modeled Respiratory Tract Deposition of Aerosolized Oil Diluents Used in ΔFrontiers in public health · 2021Article
- Major Constituents of Cannabis Vape Oil Liquid, Vapor and Aerosol in California Vape Oil Cartridge Samples.Frontiers in chemistry · 2021Article
- A Retrospective Analysis of Chemical Constituents in Regulated and Unregulated E-Cigarette Liquids.Frontiers in chemistry · 2021Article
- Aerosol droplet-size distribution and airborne nicotine portioning in particle and gas phases emitted by electronic cigarettes.Scientific reports · 2020Article
- Inhalation Toxicology of Vaping Products and Implications for Pulmonary Health.International journal of molecular sciences · 2020Review
- Nicotine e-cigarette vapor inhalation effects on nicotine & cotinine plasma levels and somatic withdrawal signs in adult male Wistar rats.Psychopharmacology · 2020Article
- The Analysis of Aerosolized Methamphetamine From E-cigarettes Using High Resolution Mass Spectrometry and Gas Chromatography Mass Spectrometry.Journal of analytical toxicology · 2019Article
- Design Features in Multiple Generations of Electronic Cigarette Atomizers.International journal of environmental research and public health · 2019Article
- The Effect of Electronic Cigarette User Modifications and E-liquid Adulteration on the Particle Size Profile of an Aerosolized Product.Scientific reports · 2019Article
- Common E-Cigarette Flavoring Chemicals Impair Neutrophil Phagocytosis and Oxidative Burst.Chemical research in toxicology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Electronic cigarettes (e-cigs) deliver nicotine in an aerosol to the user that simulates the smoke of traditional cigarettes purportedly without the pathology of inhaling tobacco smoke due to the absence of combustion. Advanced versions of e-cigs enable the user to potentially moderate the concentration of drug in the aerosol by selecting from a range of voltages on the power supply. A method was developed to trap the aerosol produced by a KangerTech AeroTank, 1.8 Ω preassembled atomizer in order to analyze the concentration of nicotine and to evaluate the constituents of the aerosol at various voltages on the power supply. A 12-mg/mL formulation of nicotine in 50:50 propylene glycol (PG):vegetable glycerin (VG) was used to produce aerosol at 3.9, 4.3 and 4.7 V. The aerosol was trapped in a simple glass assemblage and analyzed by a 3200 Q Trap HPLC-MS-MS. The dose of nicotine delivered in the aerosol at 3.9, 4.3 and 4.7 V was determined to be 88 ± 12 μg, 91 ± 15 μg and 125 ± 22 μg. The average recovery of nicotine in the trap across the voltages was 99.8%. The glass trap system was an effective device for collecting the aerosol for analysis and an increase in drug yield was observed with increasing voltage from the power supply on the e-cig. The glass trap system was also used in combination with a 100-μm solid-phase microextraction fiber to capture the aerosol and analyze it via DART-MS and GC-MS. Four commercial e-liquids labeled to contain nicotine were aerosolized at 4.3 V. The pharmacologically active ingredient, nicotine, as well as PG, VG and a number of flavoring agents found in these formulations were identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.