ArticleGenome biology and evolution2018
Accelerated Laboratory Evolution Reveals the Influence of Replication on the GC Skew in Escherichia coli.
Article in Genome biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- On the origins and variation of nucleotide skews of archaeal genomes.Frontiers in microbiology · 2026Article
- The first complete mitochondrial genome of Spinturnix psi (Dermanyssoidea, Spinturnicidae): gene content, composition, rearrangement and phylogenetic implications.Experimental & applied acarology · 2025Article
- Terrestrial Adaptation inGenes · 2025Article
- Analysis of the Complete Mitochondrial Genome ofAnimals : an open access journal from MDPI · 2023Article
- Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria.Microbial genomics · 2022Article
- Analysis of Complete Mitochondrial Genome ofAnimals : an open access journal from MDPI · 2022Article
- Article
- Delineation of the Ancestral Tus-Dependent Replication Fork Trap.International journal of molecular sciences · 2021Article
- Mitochondrial mutations in Caenorhabditis elegans show signatures of oxidative damage and an AT-bias.Genetics · 2021Article
- Article
- Article
- Potential causes and consequences of rapid mitochondrial genome evolution in thermoacidophilic Galdieria (Rhodophyta).BMC evolutionary biology · 2020Article
- Evolutionary advantage of anti-parallel strand orientation of duplex DNA.Scientific reports · 2020Article
- Strand-specific Single-stranded DNA Sequencing (4S-seq) ofBio-protocol · 2019Article
Corrections and comments
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most bacterial genomes display contrasting strand asymmetry in a variety of features, such as nucleotide composition and gene orientation, of the two replichores separated by the replication origin and terminus. The cause for the polarization is often attributed to mutations arising from the asymmetric replication machinery. Notably, a base compositional bias known as a GC skew is focused on as a footprint of the bacterial genome evolution driven by DNA replication. Previously, although a replication driven mutation pattern responsible for the GC skew formation or the related mathematical models have been well reported, an exact impact of the replication-related elements on the genomic structure is yet actively debated, and not confirmed experimentally. However, the GC skew formation is very time consuming and challenging in the laboratory. We, therefore, used cytosine deaminase as a DNA mutator, and by monitoring the mutations during an accelerated laboratory evolution procedure with Illumina sequencing, we enabled the trial and error of the GC skew formation in high resolution. Using this technology, we succeeded in reconfirming the influence of bacterial replication machinery on the genomic structure at high resolution.
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