ArticleJournal of visualized experiments : JoVE2018
Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling.
Article in Journal of visualized experiments : JoVE, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Temporal drift of sleep-wake representations in hypothalamic neuronal ensembles.Nature communications · 2026Article
- Article
- Molecularly distinct subtypes ofiScience · 2026Article
- Dualistic and inconsistent role of total and rapid-eye movement (REM) sleep deprivation on depressive-like behaviors in rats: a systematic review.Sleep and biological rhythms · 2025Review
- Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.Sleep · 2025Article
- Sleep deprivation affects memory function, depression and anxiety-like behaviours in rats and mice: a systematic review and meta-analysis.Brain communications · 2025Review
- Isoflurane anesthesia and sleep deprivation trigger delayed and selective sleep alterations.Scientific reports · 2024Article
- Selective REM sleep restriction in mice using a device designed for tunable somatosensory stimulation.Journal of neuroscience methods · 2024Article
- Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice.Brain and behavior · 2023Article
- Behavioral and Molecular Consequences of Chronic Sleep Restriction During Development in Fragile X Mice.Frontiers in neuroscience · 2022Article
- Effects of Treatment With Hypnotics on Reduced Sleep Duration and Behavior Abnormalities in a Mouse Model of Fragile X Syndrome.Frontiers in neuroscience · 2022Article
- Alterations of the Gut Microbiota in Response to Total Sleep Deprivation and Recovery Sleep in Rats.Nature and science of sleep · 2022Article
- The Ontogenesis of Mammalian Sleep: Form and Function.Current sleep medicine reports · 2020Article
- Sleep-deprived cognitive impairment in aging mice is alleviated by rapamycin.Aging pathobiology and therapeutics · 2019Article
- Chronic Sleep Restriction in Developing Male Mice Results in Long Lasting Behavior Impairments.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sleep is critical for proper development and neural plasticity. Moreover, abnormal sleep patterns are characteristic of many neurodevelopmental disorders. Studying how chronic sleep restriction during development can affect adult behavior may add to our understanding of the emergence of behavioral symptoms of neurodevelopmental disorders. While there are many methods that can be used to restrict sleep in rodents including forced locomotion, constant disruption, presentation of an aversive stimulus, or electric shock, many of these methods are very stressful and cannot be used in neonatal mice. Here, we describe gentle handling, a sleep deprivation technique that can be used chronically throughout development and into adulthood to achieve sleep restriction. Gentle handling involves close observation of the mice throughout the sleep deprivation period and requires the researcher to gently prod the animals whenever they are inactive or display behaviors associated with sleep. Coupled with EEG recordings, gentle handling could be used to selectively disrupt a specific phase of sleep such as rapid eye movement (REM) sleep. The technique of gentle handling is a powerful tool for the study of the effects of chronic sleep restriction even in neonatal mice that circumvents many of the more stressful procedures used for sleep deprivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.