Evidence map›Paper›PMID 30371569›Full record

Observational studyCornea2019

Classification of Limbal Stem Cell Deficiency Using Clinical and Confocal Grading.

Carolina Aravena, Kansu Bozkurt, Pichaya Chuephanich, Chantaka Supiyaphun, Fei Yu, Sophie X Deng

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cornea, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. [Limbal diseases].Die Ophthalmologie · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
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  11. Review
  12. Limbal stem cell diseases.Experimental eye research · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

Carolina AravenaCornea Division, Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA.
Kansu BozkurtCornea Division, Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA.
Pichaya ChuephanichCornea Division, Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA.
Chantaka SupiyaphunCornea Division, Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA.
Fei YuCornea Division, Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA.
Sophie X DengCornea Division, Stein Eye Institute, Department of Ophthalmology, University of California, Los Angeles, CA.
University of California, Los Angeles · USPhramongkutklao College of MedicinePontificia Universidad Católica de Chile · CLSağlık Bilimleri Üniversitesi · TRVajira Hospital · TH

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
Ex Vivo Expansion of Human Limbal Stem Cells for TransplantationR01EY021797 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sophie Deng · 2012 to 2026
$5.1M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY021797
6 · The paper itself

Abstract

purposeTo grade the severity of limbal stem cell deficiency (LSCD) based on the extent of clinical presentation and central corneal basal epithelial cell density (BCD).

methodsThis is a retrospective observational comparative study of 48 eyes of 35 patients with LSCD and 9 eyes of 7 normal subjects (controls). Confocal images of the central cornea were acquired. A clinical scoring system was created based on the extent of limbal and corneal surface involvement. LSCD was graded as mild, moderate, and severe stages based on the clinical scores. The degree of BCD reduction was given a score of 0 to 3.

resultsCompared with BCD in controls, BCD decreased by 23.0%, 40.4%, and 69.5% in the mild, moderate, and severe stages of LSCD classified by the clinical scoring system, respectively. The degree of BCD reduction was positively correlated with larger limbal and corneal surface involvement and when the central visual axis was affected (all P ≤ 0.0005). Mean corrected distance visual acuity logarithm of the minimum angle of resolution was 0.0 ± 0.0 in control eyes, 0.2 ± 0.5 in mild LSCD, 0.6 ± 0.4 in moderate LSCD, and 1.6 ± 1.1 in severe LSCD (P < 0.0001). There was a significant correlation between a higher clinical score and corrected distance visual acuity logarithm of the minimum angle of resolution (rho = 0.82; P < 0.0001) and a greater decrease in BCD (rho = -0.78; P < 0.0001).

conclusionsA clinical scoring system was developed to assess the extent of clinical presentation of LSCD. A classification system to grade the severity of LSCD can be established by combining the BCD score with the clinical score.

Indexed as

AdultAgedAged, 80 and overCorneal DiseasesCross-Sectional StudiesFemaleFollow-Up StudiesHumansLimbus CorneaeMaleMicroscopy, ConfocalMiddle AgedRetrospective StudiesSeverity of Illness IndexStem CellsYoung Adult

Identifiers

PMID30371569
PMCPMC6279551
OpenAlexW2898101134

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.