ArticleIEEE transactions on bio-medical engineering2019
Viscoelastic Properties of Human Autopsy Brain Tissues as Biomarkers for Alzheimer's Diseases.
Article in IEEE transactions on bio-medical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood-brain barrier.Nature biomedical engineering · 2025Pooled it
- Viscoelasticity of the Heart: An Overview of Viscoelastic Measurements at Different Scales.Annual review of biomedical engineering · 2026Review
- Integrated nanoindentation-Raman spectroscopy reveals microscale biomechanical and molecular biomarkers of early intervertebral disc degeneration in a rat model.Materials today. Bio · 2025Article
- Mechanical characterization of brain tissue: experimental techniques, human testing considerations, and perspectives.Acta biomaterialia · 2025Review
- Article
- Model-driven exploration of poro-viscoelasticity in human brain tissue: be careful with the parameters!Interface focus · 2024Article
- Diabetes and Cognitive Decline: An Innovative Approach to Analyzing the Biophysical and Vibrational Properties of the Hippocampus.ACS omega · 2024Article
- Review
- Photoacoustic viscoelasticity assessment of prefrontal cortex and cerebellum in normal and prenatal valproic acid-exposed rats.Photoacoustics · 2024Article
- Dynamic Hydrogels with Viscoelasticity and Tunable Stiffness for the Regulation of Cell Behavior and Fate.Materials (Basel, Switzerland) · 2023Review
- Advanced 3D Models of Human Brain Tissue Using Neural Cell Lines: State-of-the-Art and Future Prospects.Cells · 2023Review
- Phase-Resolved Optical Coherence Elastography: An Insight into Tissue Displacement Estimation.Sensors (Basel, Switzerland) · 2023Article
- Unravelling the mechanotransduction pathways in Alzheimer's disease.Journal of biological engineering · 2023Review
- Orientation-dependent indentation reveals the crosslink-mediated deformation mechanisms of collagen fibrils.Acta biomaterialia · 2023Article
- Review
- Article
- Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics.Frontiers in cell and developmental biology · 2021Review
- Unraveling the Local Relation Between Tissue Composition and Human Brain Mechanics Through Machine Learning.Frontiers in bioengineering and biotechnology · 2021Article
- Standard-space atlas of the viscoelastic properties of the human brain.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe present study investigates viscoelastic properties of human autopsy brain tissue via nanoindentation to find feasible biomarkers for Alzheimer's disease (AD) in ex vivo condition and to understand the mechanics of the human brain better, especially on the difference before and after progression of AD.
methodsViscoelastic properties of paraformaldehyde-fixed, paraffin-embedded thin (8 [Formula: see text]) sectioned normal and AD affected human autopsy brain tissue samples are investigated via nanoindentation with a combined loading profile of a linear preloading and a sinusoidal loading at various loading frequencies from 0.01 to 10 [Formula: see text]. In 1200 indentation tests for ten human autopsy brain tissue samples from ten different subjects (five AD cases and five normal controls), viscoelastic properties such as Young's modulus, storage modulus, loss modulus, and loss factor of both gray and white matter brain tissues samples from normal and AD affected tissues were measured experimentally.
resultsWe found that the normal brain tissues have higher Young's modulus values than the AD affected brain tissues by 23.5 % and 27.9 % on average for gray and white matter, respectively, with statistically significant differences ( ) between the normal and AD affected brain tissues. Additionally, the AD affected brain tissues have much higher loss factor than the normal brain tissues on lower loading frequencies. SIGNIFICANCE: AD is one of the leading causes of death in America and continues to affect a growing population. The challenges of recognizing the early pathological changes in brain tissue due to AD and diagnosing a patient has led to much research focused on finding biomarkers for the disease. In this regard, understanding the mechanics of brain tissues is increasingly recognized to play an important role in diagnosing brain diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.