ArticleJournal of the American Heart Association2018
CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias.
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Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Elimination of myotonia improves myopathy in a muscleblind-like knockout model of myotonic dystrophy.Nature communications · 2026Article
- Ancestral intronic splicing regulatory elements in the SCNbioRxiv : the preprint server for biology · 2026Article
- Cardiac Involvement in Myotonic Dystrophy Type 1: Mechanisms, Clinical Perspectives, and Emerging Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Myotonic dystrophy type 1: clinical diversity, molecular insights and therapeutic perspectives.Nature reviews. Neurology · 2025Review
- Elimination of myotonia improves myopathy in a muscleblind knockout model of myotonic dystrophy.bioRxiv : the preprint server for biology · 2025Article
- MBNL overexpression rescues cardiac phenotypes in a myotonic dystrophy type 1 heart mouse model.The Journal of clinical investigation · 2025Article
- Rescue of Scn5a mis-splicing does not improve the structural and functional heart defects of a DM1 heart mouse model.Human molecular genetics · 2024Article
- Protein isoform-centric therapeutics: expanding targets and increasing specificity.Nature reviews. Drug discovery · 2024Review
- Verapamil mitigates chloride and calcium bi-channelopathy in a myotonic dystrophy mouse model.The Journal of clinical investigation · 2024Article
- Posttranscriptional Regulation by Proteins and Noncoding RNAs.Advances in experimental medicine and biology · 2024Article
- Development and disease-specific regulation of RNA splicing in cardiovascular system.Frontiers in cell and developmental biology · 2024Review
- BlockmiR AONs as Site-Specific Therapeutic MBNL Modulation in Myotonic Dystrophy 2D and 3D Muscle Cells and HSAPharmaceutics · 2023Article
- Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia.Cardiovascular research · 2023Article
- Cardiac involvement in patient-specific induced pluripotent stem cells of myotonic dystrophy type 1: unveiling the impact of voltage-gated sodium channels.Frontiers in physiology · 2023Article
- Clinical and Molecular Insights into Gastrointestinal Dysfunction in Myotonic Dystrophy Types 1 & 2.International journal of molecular sciences · 2022Review
- Mice lacking MBNL1 and MBNL2 exhibit sudden cardiac death and molecular signatures recapitulating myotonic dystrophy.Human molecular genetics · 2022Article
- Developmental changes in cardiac expression of KCNQ1 and SCN5A spliceoforms: Implications for sudden unexpected infant death.Heart rhythm · 2022Article
- Cardiac Pathology in Myotonic Dystrophy Type 1.International journal of molecular sciences · 2021Review
- Reversible cardiac disease features in an inducible CUG repeat RNA-expressing mouse model of myotonic dystrophy.JCI insight · 2021Article
- Targeted splice sequencing reveals RNA toxicity and therapeutic response in myotonic dystrophy.Nucleic acids research · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Paul D Pang1 Department of Molecular Physiology & Biophysics Baylor College of Medicine Houston TX.
Katherina M Alsina1 Department of Molecular Physiology & Biophysics Baylor College of Medicine Houston TX.
Shuyi Cao1 Department of Molecular Physiology & Biophysics Baylor College of Medicine Houston TX.
Amrita B Koushik2 Department of Pathology & Immunology Baylor College of Medicine Houston TX.
Xander H T Wehrens1 Department of Molecular Physiology & Biophysics Baylor College of Medicine Houston TX.
Thomas A Cooper1 Department of Molecular Physiology & Biophysics Baylor College of Medicine Houston TX.
Baylor College of Medicine · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MUM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MMOLECULAR PATHOGENESIS OF MYOTONIC DYSTROPHYR01AR045653 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI COOPER, THOMAS A · 1999 to 2018
$8.3MMolecular Physiology of the Cardiovascular SystemT32HL007676 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L · 1989 to 2020
$7.9MRyanodine receptor regulation in post-operative atrial fibrillationR01HL089598 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2007 to 2022
$6.5MTROPONIN T ALTERNATIVE SPLICING IN EMBRYONIC HEARTR01HL045565 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI COOPER, THOMAS A · 1996 to 2018
$5.5MMETABOLIC IMPACTS OF TYPE II INTERFERON SIGNALS IN OBESITYR01DK114356 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI HARTIG, SEAN · 2017 to 2025
$4.6MTranscriptome processing networks in skeletal muscle: mechanisms and functionsR01AR060733 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI COOPER, THOMAS A · 2011 to 2023
$4.0MRegulation of Sarcoplasmic Reticulum Calcium Release in Heart FailureR01HL091947 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2009 to 2019
$3.2MDetermining the Role of Junctophilin-2 in Cardiac DiseaseR01HL117641 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2014 to 2017
$2.3MMis-splicing of Scn5a and its effect on the heart in myotonic dystrophyF31HL140879 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI PANG, PAUL · 2018 to 2019
$52kNCI NIH HHS P30 CA125123NHGRI NIH HHS UM1 HG006348NHLBI NIH HHS F31 HL140879NHLBI NIH HHS R01 HL045565NHLBI NIH HHS R01 HL089598NHLBI NIH HHS R01 HL091947NHLBI NIH HHS R01 HL117641NHLBI NIH HHS T32 HL007676NIAMS NIH HHS R01 AR045653NIAMS NIH HHS R01 AR060733NIDDK NIH HHS R01 DK114356
Abstract
Background The sodium channel, Na
Indexed as
Gene Expression Regulation, DevelopmentalPregnancy, AnimalAllelesAnimalsArrhythmias, CardiacClustered Regularly Interspaced Short Palindromic RepeatsDisease Models, AnimalElectrocardiographyFemaleHeart Conduction SystemMaleMiceMice, TransgenicNAV1.5 Voltage-Gated Sodium ChannelPhenotypePregnancyNAV1.5 Voltage-Gated Sodium ChannelRNAScn5a protein, mousealternative splicingarrhythmiaconductionmyotonic dystrophy cardiomyopathySCN5A
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.