Evidence map›Paper›PMID 30371306›Full record

ArticleJournal of the American Heart Association2018

Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1.

Rui Wang, Weibin Wu, Wen Li, Shuichuan Huang, Zilun Li, Ruiming Liu, Zhen Shan, Chunxiang Zhang, Wen Li, Shenming Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  5. IGF2BP1 modulates ZDHHC5-mediated NLRP3 inflammasome activation to promote mitochondrial damage and foam cell formation of vascular smooth muscle cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Involvement of role of HMGB1-NLRP3 pathway in systemic disorders.Frontiers in cell and developmental biology · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Rui Wang1 Division of Vascular Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat-sen University Guangzhou China.
Weibin Wu1 Division of Vascular Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat-sen University Guangzhou China.
Wen Li1 Division of Vascular Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat-sen University Guangzhou China.
Shuichuan Huang1 Division of Vascular Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat-sen University Guangzhou China.
Zilun Li1 Division of Vascular Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat-sen University Guangzhou China.
Ruiming Liu2 Laboratory of General Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat-sen University Guangzhou China.
Zhen Shan1 Division of Vascular Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat-sen University Guangzhou China.
Chunxiang Zhang3 Department of Biomedical Engineering School of Medicine University of Alabama at Birmingham AL.
Wen Li2 Laboratory of General Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat-sen University Guangzhou China.
Shenming Wang1 Division of Vascular Surgery Guangdong Key Engineering Laboratory for Diagnosis and Treatment of Vascular Disease First Affiliated Hospital Sun Yat-sen University Guangzhou China.
The First Affiliated Hospital, Sun Yat-sen University · CNSun Yat-sen University · CNUniversity of Alabama at Birmingham · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background This study aimed at investigating whether NLRP 3 (the Nod like receptor family, pyrin domain-containing 3 protein) inflammasome activation induced HMGB 1 (high mobility group box-1 protein) secretion and foam cell formation in human vascular smooth muscle cells ( VSMC s) and atherosclerosis in ApoE

Indexed as

Gene Expression RegulationAnimalsAtherosclerosisCells, CulturedDisease Models, AnimalFoam CellsHMGB1 ProteinHumansInflammasomesMaleMiceMice, KnockoutMuscle, Smooth, VascularNLR Family, Pyrin Domain-Containing 3 ProteinRNASignal TransductionHMGB1 ProteinHMGB1 protein, mouseInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseRNAATP‐binding cassette transporterfoam cellsLipid metabolitesNod like receptor family, pyrin domain‐containing 3 proteinreceptor for advanced glycation end product

Identifiers

PMID30371306
PMCPMC6404867
OpenAlexW2893567108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.