ArticleJournal of the American Heart Association2018
Is Baseline Orthostatic Hypotension Associated With a Decline in Global Cognitive Performance at 4-Year Follow-Up? Data From TILDA (The Irish Longitudinal Study on Ageing).
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Orthostatic Blood Pressure Recovery Is Associated With the Rate of Cognitive Decline and Mortality in Clinical Alzheimer's Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- Blood Pressure Lowering With Nilvadipine in Patients With Mild-to-Moderate Alzheimer Disease Does Not Increase the Prevalence of Orthostatic Hypotension.Journal of the American Heart Association · 2019Trial
- Orthostatic hypotension without co-existent supine hypertension is associated with impaired cerebral oxygenation: findings from the Irish Longitudinal Study on Ageing (TILDA).Journal of human hypertension · 2026Article
- Responses to active stand test predict 12-year incident cardiovascular disease and mortality.Communications medicine · 2025Article
- The association between STOPPFall medication use and orthostatic hypotension in community-dwelling older people.Age and ageing · 2025Article
- Cohort Profile Update: The Harmonised Cognitive Assessment Protocol Sub-study of The Irish Longitudinal Study on Ageing (TILDA-HCAP).International journal of epidemiology · 2024Article
- The Impact of Type 2 Diabetes on Peripheral and Cerebral Hemodynamic Responses to Active Stand.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Slower speed of blood pressure recovery after standing is associated with accelerated brain aging: Evidence from The Irish Longitudinal Study on Ageing (TILDA).Cerebral circulation - cognition and behavior · 2024Article
- The 'Bermuda Triangle' of orthostatic hypotension, cognitive impairment and reduced mobility: prospective associations with falls and fractures in The Irish Longitudinal Study on Ageing.Age and ageing · 2023Article
- Increased multimorbidity is associated with impaired cerebral and peripheral hemodynamic stabilization during active standing.Journal of the American Geriatrics Society · 2022Article
- Impaired Stabilization of Orthostatic Cerebral Oxygenation Is Associated With Slower Gait Speed: Evidence From The Irish Longitudinal Study on Ageing.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Associations between Cardiovascular Signal Entropy and Cognitive Performance over Eight Years.Entropy (Basel, Switzerland) · 2021Article
- From Normal Cognition to Cognitive Impairment and Dementia: Impact of Orthostatic Hypotension.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Longitudinal relation between blood pressure, antihypertensive use and cerebral blood flow, using arterial spin labelling MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Orthostatic hypotension in older people: considerations, diagnosis and management.Clinical medicine (London, England) · 2021Review
- Intermittent compression of the calf muscle as a countermeasure to protect blood pressure and brain blood flow in upright posture in older adults.European journal of applied physiology · 2021Article
- Systemic and cerebral circulatory adjustment within the first 60 s after active standing: An integrative physiological view.Autonomic neuroscience : basic & clinical · 2021Review
- Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders.Current topics in behavioral neurosciences · 2021Review
- Orthostatic hypotension is not associated with small vessel disease progression or cognitive decline.Cerebral circulation - cognition and behavior · 2021Review
- Home-measured orthostatic hypotension associated with cerebral small vessel disease in a community-based older population.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background It is postulated that orthostatic hypotension ( OH ), a reduction in blood pressure (≥20/10 mm Hg) within 3 minutes of standing, may increase cognitive decline because of cerebral hypoperfusion. This study assesses the impact of OH on global cognition at 4-year follow-up, and the impact of age and hypertension on this association. Methods and Results Data from waves 1 and 3 of TILDA (The Irish Longitudinal Study on Ageing) were used. Baseline blood pressure response to active stand was assessed using beat-to-beat blood pressure monitoring. Two measures of OH were used-at 40 seconds ( OH 40) and 110 seconds ( OH 110). Global cognition was measured using the Montreal Cognitive Assessment. Mixed-effects Poisson regression assessed whether baseline OH was associated with a decline in global cognition at 4-year follow-up. The analysis was repeated, stratifying by age (age 50-64 years and age ≥65 years), and including an interaction between OH and hypertension. Baseline OH 110 was associated with an increased error rate in Montreal Cognitive Assessment at follow-up (incident rate ratio 1.17, P=0.028). On stratification by age, the association persists in ages 50 to 64 years (incident rate ratio 1.25, P=0.048), but not ages ≥65 years. Including an interaction with hypertension found those with co-existent OH 110 and hypertension (incident rate ratio 1.27, P=0.011), or OH 40 and hypertension (incident rate ratio 1.18, P=0.017), showed an increased error rate; however, those with isolated OH 110, OH 40, or isolated hypertension did not. Conclusions OH is associated with a decline in global cognition at 4-year follow-up, and this association is dependent on age and co-existent hypertension.
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