Evidence map›Paper›PMID 30371297›Full record

SynthesisJournal of the American Heart Association2018

Statins Reduce Abdominal Aortic Aneurysm Growth, Rupture, and Perioperative Mortality: A Systematic Review and Meta-Analysis.

Konrad Salata, Muzammil Syed, Mohamad A Hussain, Charles de Mestral, Elisa Greco, Muhammad Mamdani, Jack V Tu, Thomas L Forbes, Deepak L Bhatt, Subodh Verma and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 10 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 10 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Guideline
  8. Guideline
  9. Pooled it
  10. Pharmacotherapy in Clinical Trials for Abdominal Aortic Aneurysms: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  11. Abdominal aortic aneurysm progression: A review of preclinical and clinical data.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Review
  12. The Role of miR-501-3p in Abdominal Aortic Aneurysm Progression: A Pilot Study.Journal of cardiovascular translational research · 2026
    Article
  13. Review
  14. Value-Based Medicine in the Management of Abdominal Aortic Aneurysms.Journal of the American Heart Association · 2026
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Konrad Salata1 Division of Vascular Surgery Department of Surgery University of Toronto Ontario Canada.
Muzammil Syed3 Faculty of Science McMaster University Hamilton Ontario Canada.
Mohamad A Hussain1 Division of Vascular Surgery Department of Surgery University of Toronto Ontario Canada.
Charles de Mestral1 Division of Vascular Surgery Department of Surgery University of Toronto Ontario Canada.
Elisa Greco1 Division of Vascular Surgery Department of Surgery University of Toronto Ontario Canada.
Muhammad Mamdani4 Li Ka Shing Centre for Healthcare Analytics Research and Training (CHART) Li Ka Shing Knowledge Institute St. Michael's Hospital Toronto Ontario Canada.
Jack V Tu7 Institute of Health Policy, Management and Evaluation Dalla Lana Faculty of Public Health University of Toronto Ontario Canada.
Thomas L Forbes1 Division of Vascular Surgery Department of Surgery University of Toronto Ontario Canada.
Deepak L Bhatt12 Brigham and Women's Hospital Heart and Vascular Center Boston MA.
Subodh Verma14 Division of Cardiac Surgery Department of Surgery University of Toronto Ontario Canada.
Mohammed Al-Omran1 Division of Vascular Surgery Department of Surgery University of Toronto Ontario Canada.
St. Michael's Hospital · CAUniversity of Toronto · CABrigham and Women's Hospital · USInstitute for Clinical Evaluative Sciences · CAMcMaster University · CAPublic Health Ontario · CAToronto General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background There are no recognized pharmacological treatments for abdominal aortic aneurysms ( AAA ), although statins are suggested to be beneficial. We sought to summarize the literature regarding the effects of statins on human AAA growth, rupture, and 30-day mortality. Methods and Results We conducted a systematic review and meta-analysis of randomized and observational studies using the Cochrane CENTRAL database, MEDLINE , and EMBASE up to June 15, 2018. Review, abstraction, and quality assessment were conducted by 2 independent reviewers, and a third author resolved discrepancies. Pooled mean differences and odds ratios with 95% confidence intervals were calculated using random effects models. Heterogeneity was quantified using the I

Indexed as

Aneurysm, RupturedAortic Aneurysm, AbdominalDisease ProgressionGlobal HealthHumansHydroxymethylglutaryl-CoA Reductase InhibitorsPerioperative CareSurvival RateVascular Surgical ProceduresHydroxymethylglutaryl-CoA Reductase Inhibitorsaneurysmmeta‐analysisrupturestatinsystematic review

Identifiers

PMID30371297
PMCPMC6404894
OpenAlexW2892819682

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.