Observational studyJournal of the American Heart Association2018
Relations of Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness in Blacks: The Jackson Heart Study.
Observational study in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Relations of Life's Essential 8 score with arterial and microvascular function: The Jackson Heart Study.Vascular medicine (London, England) · 2026Article
- Associations of noninvasive measures of adiposity with aortic stiffness and microvascular function: The Jackson Heart Study.American journal of preventive cardiology · 2026Article
- Association of Physical Activity With Aortic Stiffness in the Jackson Heart Study.American journal of hypertension · 2026Article
- Relations of Artificial Intelligence Vascular Age With Cardiometabolic Disease Progression: The Framingham Heart Study.Journal of the American Heart Association · 2025Article
- Relationship between estimated pulse wave velocity and the risk of future sarcopenia in middle-aged and older Chinese adults: evidence from the China Health and Retirement Longitudinal Study.Frontiers in cardiovascular medicine · 2025Article
- Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Microvascular vasoregulatory dysfunction in African Americans - An enhanced opportunity for early prevention and treatment of atherosclerotic cardiovascular disease.American heart journal plus : cardiology research and practice · 2024Article
- Brachial-Ankle Pulse Wave Velocity Mediates the Association between Increased Age and Risk of Sarcopenia among Chinese Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2023Article
- Prevalence, Predictors, Progression, and Prognosis of Hypertension Subtypes in the Framingham Heart Study.Journal of the American Heart Association · 2022Article
- The contributory role of vascular health in age-related anabolic resistance.Journal of cachexia, sarcopenia and muscle · 2022Review
- The association between pulse wave analysis, carotid-femoral pulse wave velocity and peripheral arterial disease in patients with ischemic heart disease.BMC cardiovascular disorders · 2021Article
- Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes.Current topics in membranes · 2021Review
- Clinical Associations of Vascular Stiffness, Microvascular Dysfunction, and Prevalent Cardiovascular Disease in a Black Cohort: The Jackson Heart Study.Journal of the American Heart Association · 2020Article
- Association between retinal arterial narrowing and left ventricular diastolic dysfunction in masked hypertensives.Journal of clinical hypertension (Greenwich, Conn.) · 2020Observational
- Aortic Stiffness Is Associated with Coronary Microvascular Dysfunction in Patients with Non-obstructive Coronary Artery Disease.Internal medicine (Tokyo, Japan) · 2020Article
- Endothelial Cell Mechano-Metabolomic Coupling to Disease States in the Lung Microvasculature.Frontiers in bioengineering and biotechnology · 2019Review
- Relations of Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness in Blacks: The Jackson Heart Study.Journal of the American Heart Association · 2018Observational
- Kidney Function and Aortic Stiffness, Pulsatility, and Endothelial Function in African Americans: The Jackson Heart Study.Kidney medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
Background Blacks have more severe endothelial dysfunction and aortic stiffening as compared with whites. We aimed to investigate the association between aortic stiffness and microvascular function in the black community. Methods and Results We assessed the association between forearm vascular reactive hyperemia (an indicator of microvascular function) and aortic stiffness in 1458 black participants (N=965 [66% women]; mean age: 66±11 years) in the Jackson Heart Study. We evaluated 2 measures of aortic stiffness: brachial pulse pressure and carotid-femoral pulse wave velocity. Using high-resolution ultrasound and Doppler, we evaluated brachial blood flow at baseline and during reactive hyperemia after 5 minutes of forearm ischemia. Multiple cardiovascular risk factors were significantly related to baseline and hyperemic brachial flow velocity. Women had lower baseline flow across the entire age spectrum. During hyperemia, we observed a significant age-sex interaction for flow velocity ( P=0.02). Female sex was protective against microvascular dysfunction among younger participants, but older women exhibited a greater attenuation of the hyperemic flow reserve. In multivariable models that adjusted for cardiovascular disease risk factors and mean arterial pressure, higher carotid-femoral pulse wave velocity (β=-0.106±0.033; P=0.001 was related to lower baseline flow. However, during reactive hyperemia, elevated brachial pulse pressure (β=-0.070±0.031; P=0.03) and carotid-femoral pulse wave velocity (β=-0.128±0.030; P<0.001) were both related to attenuated brachial flow velocity. Conclusions In a sample of blacks, higher aortic stiffness and pressure pulsatility were associated with lower flow reserve during reactive hyperemia, beyond changes attributable to traditional cardiovascular disease risk factors alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.