Evidence map›Paper›PMID 30371258›Full record

ReviewJournal of the American Heart Association2018

Genetics of Atrial Fibrillation.

Julien Feghaly, Patrick Zakka, Barry London, Calum A MacRae, Marwan M Refaat

Abstract readReview
In one paragraph

Review in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

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  12. Modulation of NOX2 causes obesity-mediated atrial fibrillation.The Journal of clinical investigation · 2024
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  19. 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Julien Feghaly1 Department of Internal Medicine St Louis University Hospital St Louis MO.
Patrick Zakka2 Department of Internal Medicine Emory University Hospital Atlanta GA.
Barry London3 Department of Cardiovascular Medicine University of Iowa Carver College of Medicine Iowa City IA.
Calum A MacRae4 Department of Cardiovascular Medicine Brigham and Women's Hospital Boston MA.
Marwan M Refaat5 Department of Cardiovascular Medicine American University of Beirut Medical Center Beirut Lebanon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Atrial fibrillation ( AF ) is a common arrhythmia seen in clinical practice. Occasionally, no common risk factors are present in patients with this arrhythmia. This suggests the potential underlying role of genetic factors associated with predisposition to developing AF . Methods and Results We conducted a comprehensive review of the literature through large online libraries, including PubMed. Many different potassium and sodium channel mutations have been discussed in their relation to AF . There have also been non-ion channel mutations that have been linked to AF . Genome-wide association studies have helped in identifying potential links between single-nucleotide polymorphisms and AF . Ancestry studies have also highlighted a role of genetics in AF . Blacks with a higher percentage of European ancestry are at higher risk of developing AF . The emerging field of ablatogenomics involves the use of genetic profiles in their relation to recurrence of AF after catheter ablation. Conclusions The evidence for the underlying role of genetics in AF continues to expand. Ultimately, the role of genetics in risk stratification of AF and its recurrence is of significant interest. No established risk scores that are useful in clinical practice are present to date.

Indexed as

Atrial FibrillationAtrial Natriuretic FactorCalciumCatheter AblationGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHomeostasisHumansLaminsMutationNeovascularization, PhysiologicNuclear PorePedigreePotassium ChannelsSodium ChannelsAtrial Natriuretic FactorCalciumLaminsPotassium ChannelsSodium Channelsablatogenomicsancestry studiesatrial fibrillationgeneticsgenome‐wide association studies

Identifiers

PMID30371258
PMCPMC6474960

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.