Evidence map›Paper›PMID 30371217›Full record

ArticleJournal of the American Heart Association2018

Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire-Injured Carotid Artery of Male Mice.

Kamalika Mukherjee, Chi Young Song, Anne M Estes, Ahmad N Dhodi, Benjamin H Ormseth, Ji Soo Shin, Frank J Gonzalez, Kafait U Malik

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kamalika Mukherjee1 Department of Pharmacology College of Medicine University of Tennessee Health Science Center Memphis TN.
Chi Young Song1 Department of Pharmacology College of Medicine University of Tennessee Health Science Center Memphis TN.
Anne M Estes1 Department of Pharmacology College of Medicine University of Tennessee Health Science Center Memphis TN.
Ahmad N Dhodi1 Department of Pharmacology College of Medicine University of Tennessee Health Science Center Memphis TN.
Benjamin H Ormseth1 Department of Pharmacology College of Medicine University of Tennessee Health Science Center Memphis TN.
Ji Soo Shin1 Department of Pharmacology College of Medicine University of Tennessee Health Science Center Memphis TN.
Frank J Gonzalez2 Laboratory of Metabolism National Cancer Institute Bethesda MD.
Kafait U Malik1 Department of Pharmacology College of Medicine University of Tennessee Health Science Center Memphis TN.
University of Tennessee Health Science Center · USNational Cancer Institute · US

Funding

Xenobiotic ReceptorsZIABC005708 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GONZALEZ, FRANK J · 2009 to 2025
$16.4M
Angiotensins, Prostaglandins and Adrenergic InteractionsR01HL019134 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KAFAIT U MALIK · 1985 to 2026
$14.7M
Eicosanoid-Induced Vascular Growth During InjuryR01HL079109 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MALIK, KAFAIT U · 2005 to 2015
$3.3M
NHLBI NIH HHS R01 HL019134NHLBI NIH HHS R01 HL079109
6 · The paper itself

Abstract

Background We have reported that cytochrome P450 1B1 ( CYP 1B1), expressed in cardiovascular tissues, contributes to angiotensin II -induced vascular smooth muscle cell ( VSMC ) migration and proliferation and development of hypertension in various experimental animal models via generation of reactive oxygen species. This study was conducted to determine the contribution of CYP 1B1 to platelet-derived growth factor-BB-induced VSMC migration and proliferation in vitro and to neointimal growth in vivo. Methods and Results VSMC s isolated from aortas of male Cyp1b1

Indexed as

Gene Expression RegulationOxidative StressAnimalsBlotting, WesternCarotid ArteriesCarotid Artery InjuriesCell ProliferationCells, CulturedCytochrome P-450 CYP1B1Disease Models, AnimalMaleMiceMice, Inbred C57BLNeointimaRNACyp1b1 protein, mouseCytochrome P-450 CYP1B1RNAcytochrome P450 enzymesneointimaplatelet‐derived growth factorreactive oxygen speciesvascular smooth muscle cell

Identifiers

PMID30371217
PMCPMC6222936
OpenAlexW2891371148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.