Evidence map›Paper›PMID 30371213›Full record

ArticleJournal of the American Heart Association2018

Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA 4-Dependent CCN 1 Secretion.

Sumei Cui, Li Xue, Feihong Yang, Shuai Dai, Ziqi Han, Kai Liu, Baoshan Liu, Qiuhuan Yuan, Zhaoqiang Cui, Yun Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 66 citations in OpenAlex.

  1. Review
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  4. Article
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  6. Integrating Senescence and Oxidative Stress in Cardiac Disease.International journal of molecular sciences · 2025
    Review
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  8. Review
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  10. Review
  11. Article
  12. Review
  13. Review
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  15. Article
  16. Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Sumei Cui1 Department of Emergency Qilu Hospital Shandong University Jinan China.
Li Xue1 Department of Emergency Qilu Hospital Shandong University Jinan China.
Feihong Yang1 Department of Emergency Qilu Hospital Shandong University Jinan China.
Shuai Dai1 Department of Emergency Qilu Hospital Shandong University Jinan China.
Ziqi Han1 Department of Emergency Qilu Hospital Shandong University Jinan China.
Kai Liu6 Cardiovascular Surgery Department Qilu Hospital Shandong University Jinan China.
Baoshan Liu1 Department of Emergency Qilu Hospital Shandong University Jinan China.
Qiuhuan Yuan1 Department of Emergency Qilu Hospital Shandong University Jinan China.
Zhaoqiang Cui7 Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai China.
Yun Zhang5 Key Laboratory of Cardiovascular Remodeling & Function Research Chinese Ministry of Education & Chinese Ministry of Public Health Qilu Hospital Shandong University Jinan China.
Feng Xu1 Department of Emergency Qilu Hospital Shandong University Jinan China.
Yuguo Chen1 Department of Emergency Qilu Hospital Shandong University Jinan China.
Qilu Hospital of Shandong University · CNShandong University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Stress-induced cell premature senescence participates in a variety of tissue and organ remodeling by secreting such proteins as proinflammatory cytokines, chemokines, and growth factors. However, the role of cardiomyocyte senescence in heart remodeling after acute myocardial infarction has not been thoroughly elucidated to date. Therefore, we sought to clarify the impact of premature myocardial senescence on postinfarction heart function. Methods and Results Senescence markers, including p16

Indexed as

AnimalsBlotting, WesternCells, CulturedCellular SenescenceCysteine-Rich Protein 61Disease Models, AnimalGATA4 Transcription FactorHumansMaleMiceMice, Inbred C57BLMice, KnockoutMyocardial InfarctionMyocytes, CardiacCCN1 protein, mouseCysteine-Rich Protein 61Gata4 protein, mouseGATA4 Transcription FactorCCN1fibrosismyocardial ischemiasenescence

Identifiers

PMID30371213
PMCPMC6222958
OpenAlexW2891938307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.