Evidence map›Paper›PMID 30371199›Full record

SynthesisJournal of the American Heart Association2018

Skin Autofluorescence-Indicated Advanced Glycation End Products as Predictors of Cardiovascular and All-Cause Mortality in High-Risk Subjects: A Systematic Review and Meta-analysis.

Ivan Cavero-Redondo, Alba Soriano-Cano, Celia Álvarez-Bueno, Pedro G Cunha, Jose A Martínez-Hortelano, Miriam Garrido-Miguel, Carlos Berlanga-Macías, Vicente Martínez-Vizcaíno

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 5 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  17. Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ivan Cavero-Redondo1 Universidad de Castilla-La Mancha Health and Social Research Center Cuenca Spain.
Alba Soriano-Cano1 Universidad de Castilla-La Mancha Health and Social Research Center Cuenca Spain.
Celia Álvarez-Bueno1 Universidad de Castilla-La Mancha Health and Social Research Center Cuenca Spain.
Pedro G Cunha2 Center for the Research and Treatment of Arterial Hypertension and Cardiovascular Risk Internal Medicine Department Guimarães Portugal.
Jose A Martínez-Hortelano1 Universidad de Castilla-La Mancha Health and Social Research Center Cuenca Spain.
Miriam Garrido-Miguel1 Universidad de Castilla-La Mancha Health and Social Research Center Cuenca Spain.
Carlos Berlanga-Macías1 Universidad de Castilla-La Mancha Health and Social Research Center Cuenca Spain.
Vicente Martínez-Vizcaíno1 Universidad de Castilla-La Mancha Health and Social Research Center Cuenca Spain.
University of Castilla-La Mancha · ESUniversidad Autónoma de Chile · CLUniversity of Minho · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Chronic deposits of advanced glycation end products produced by enzymatic glycation have been suggested as predictors of atherosclerotic-related disorders. This study aimed to estimate the relationship between advanced glycation end products indicated by skin autofluorescence levels and the risk of cardiovascular and all-cause mortality based on data from observational studies. Methods and Results We systematically searched Medline, Embase, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and the Web of Science databases from their inceptions until November 2017 for observational studies addressing the association of advanced glycation end products by skin autofluorescence levels with cardiovascular and all-cause mortality. The DerSimonian and Laird random-effects method was used to compute pooled estimates of hazard ratios and their respective 95% confidence intervals for the risk of cardiovascular and all-cause mortality associated with levels of advanced glycation end products by skin autofluorescence. Ten published studies were included in the systematic review and meta-analysis. Higher skin autofluorescence levels were significantly associated with a higher pooled risk estimate for cardiovascular mortality (hazard ratio: 2.06; 95% confidence interval, 1.58-2.67), which might not be important to moderate heterogeneity (I

Indexed as

BiomarkersCardiovascular DiseasesCause of DeathGlobal HealthGlycation End Products, AdvancedHumansIncidenceLuminescent MeasurementsPredictive Value of TestsRisk AssessmentRisk FactorsSkinSurvival RateBiomarkersGlycation End Products, Advancedadvanced glycation end productscardiovascular complicationsmeta‐analysismortalityskin autofluorescence

Identifiers

PMID30371199
PMCPMC6222966
OpenAlexW2890394212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.