SynthesisJournal of the American Heart Association2018
Mild Pulmonary Hypertension Is Associated With Increased Mortality: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports.BMC pulmonary medicine · 2024Pooled it
- Mildly Elevated Pulmonary Arterial Pressure Is Associated With a High Risk of Progression to Pulmonary Hypertension and Increased Mortality: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2021Pooled it
- Mild Pulmonary Hypertension Is Associated With Increased Mortality: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2018Pooled it
- Article
- Association of ACE2 gene polymorphisms with risk of pulmonary arterial hypertension in neonates with congenital heart disease.BMC cardiovascular disorders · 2026Article
- Manual long axis strain compared to automated feature-tracking deformation imaging for identification of masked left heart involvement in pulmonary hypertension.The international journal of cardiovascular imaging · 2026Article
- Phenotypic Characterization of Unclassified Pulmonary Hypertension.Circulation. Heart failure · 2026Observational
- Significance of echocardiographic metrics including TRV and TAPSE/SPAP in mild haemodynamic pulmonary hypertension - data from EVIDENCE-PAH UK.Echo research and practice · 2026Article
- Association of echocardiographic findings with mortality: human assessment vs. automated deep learning analysis.European heart journal. Digital health · 2026Article
- Impact of the New Definition on the Prognosis of Patients With Pulmonary Hypertension Compared to the Classic Definition.Korean circulation journal · 2025Article
- Clinical research on echocardiographic screening for pulmonary hypertension: TRV >2.8 m/s and mPAP >20 mmHg.Quantitative imaging in medicine and surgery · 2025Article
- Prognostic Value of Pulmonary Hypertension as an Incidental Finding Detected by Echocardiography in Patients Without Known Cardiovascular or Pulmonary Diseases.Journal of clinical medicine · 2025Article
- Hemodynamic Definitions, Phenotypes, Pathophysiology, and Evaluation of Pulmonary Hypertension Related to Left Heart Disease.Journal of cardiovascular development and disease · 2025Review
- Global distribution of prognostically significant pulmonary pressure indicative of pulmonary hypertension.Journal of global health · 2025Article
- Potential Clinical Impact of Revised Pulmonary Hypertension Definitions at Moderate Altitude.CHEST pulmonary · 2025Article
- Prevalence and prognostic significance of pulmonary hypertension in adults with left ventricular diastolic dysfunction.Open heart · 2024Article
- microRNA-637/661 ameliorate hypoxic-induced pulmonary arterial hypertension by targeting TRIM29 signaling pathway.Scientific reports · 2024Article
- Pulmonary hypertension and lung transplantation waitlist outcomes for hypersensitivity pneumonitis.JHLT open · 2024Article
- Post-capillary pulmonary hypertension in heart failure: impact of current definition in the PH-HF multicentre study.European heart journal · 2024Article
- Life-Course Pathways to Exceptional Longevity: Evidence From the Lothian Birth Cohort of 1921.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Recent studies have demonstrated a continuum in clinical risk related to mean pulmonary artery pressure that begins at >19 mm Hg, which is below the traditional threshold used to define pulmonary hypertension ( PH ) of 25 mm Hg. Because of the implications on patient diagnosis and prognosis, the generalizability and validity of these data need further confirmation. Methods and Results Databases were searched from inception through January 31, 2018, to identify studies comparing all-cause mortality between patients with mildly elevated mean pulmonary artery pressure near but <25 mm Hg versus the referent group. The meta-analysis included 15 nonrandomized studies and 16 482 patients (7451 [45.2%] with measured or calculated mean pulmonary artery pressure of 19-24 mm Hg by right heart catheterization [n=6037] and echocardiography [n=1414] [mild PH ]). The mean duration of follow-up was 5.2 years. Compared with the referent group, mild PH was associated with an increased risk of mortality (risk ratio, 1.52; 95% confidence interval, 1.32-1.74; P<0.001; I
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