ArticleJournal of the American Heart Association2018
Differential Impact of Acute Lesions Versus White Matter Hyperintensities on Stroke Recovery.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Somatosensory Deficits After Stroke: Insights From MRI Studies.Frontiers in neurology · 2022Pooled it
- Structural Disconnections Caused by White Matter Hyperintensities in Post-Stroke Spatial Neglect.Human brain mapping · 2024Article
- Modulation of the Association Between Corticospinal Tract Damage and Outcome After Stroke by White Matter Hyperintensities.Neurology · 2024Article
- The volume and the distribution of premorbid white matter hyperintensities: Impact on post-stroke aphasia.Human brain mapping · 2024Article
- Article
- White matter hyperintensities modify relationships between corticospinal tract damage and motor outcomes after stroke.medRxiv : the preprint server for health sciences · 2023Article
- Integrative Approaches in Acute Ischemic Stroke: From Symptom Recognition to Future Innovations.Biomedicines · 2023Review
- Clinical, Neuroimaging and Robotic Measures Predict Long-Term Proprioceptive Impairments following Stroke.Brain sciences · 2023Article
- Early Subacute White Matter Hyperintensities and Recovery of Language After Stroke.Neurorehabilitation and neural repair · 2023Article
- Leukoaraiosis as a Predictor of Depression and Cognitive Impairment among Stroke Survivors: A Systematic Review.Neurology international · 2023Review
- Neuroimaging markers of dual impairment in cognition and physical performance following stroke: The Nor-COAST study.Frontiers in aging neuroscience · 2022Article
- Right hemispheric white matter hyperintensities improve the prediction of spatial neglect severity in acute stroke.NeuroImage. Clinical · 2022Article
- Differential Impact of Acute Lesions Versus White Matter Hyperintensities on Stroke Recovery.Journal of the American Heart Association · 2018Article
- Lesion locations associated with persistent proprioceptive impairment in the upper limbs after stroke.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Background Understanding how the size of acute lesions and white matter hyperintensities ( WMH ) impact stroke recovery can improve our ability to predict outcomes and tailor treatments. The aim of this exploratory study was to investigate the role of acute lesion volume and WMH volume on longitudinal recovery of specific sensory, motor, and cognitive impairments after stroke using robotic and clinical measures. Methods and Results Eighty-two individuals were assessed at 1, 6, 12, and 26 weeks poststroke with robotic tasks and commonly used clinical measures. The volumes of acute lesions and WMH were measured on fluid-attenuated inversion recovery images. Linear mixed models were used to investigate the role of acute lesions and WMH on parameters derived from the robotic tasks and clinical measures. Regression analysis determined the added value of acute lesion and WMH volumes along with measures of initial performance to predict outcomes at 6 months. Acute lesion volume has widespread effects on sensory, motor, and overall functional recovery poststroke. The impact of WMH was specific to cognitive impairments. Apart from the robotic position sense task, neither lesion volume nor WMH measure had significant ability to predict outcomes at 6 months over using initial impairment as measured by robotic assessments alone. Conclusions While acute lesion volume and WMH may impact different impairments poststroke, their clinical utility in predicting outcomes at 6 months poststroke is limited.
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