ArticleJournal of the American Heart Association2018
Micronutrient Deficiency Independently Predicts Time to Event in Patients With Heart Failure.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- A Multi-Mineral Intervention to Modulate Colonic Mucosal Protein Profile: Results from a 90-Day Trial in Human Subjects.Nutrients · 2021Trial
- Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association.Circulation · 2026Review
- Dietary Interventions in Heart Failure With Preserved Ejection Fraction: A Scoping Review.JACC. Advances · 2025Review
- Double malnutrition and associated factors in a middle-aged and older, rural South African population.BMC nutrition · 2024Article
- Diet variety sup the relationship between appetite and micronutrient intake in patients with heart failure.European journal of cardiovascular nursing · 2023Article
- Cardiac Cachexia in Left Ventricular Assist Device Recipients and the Implications of Weight Gain Early After Implantation.Journal of the American Heart Association · 2023Article
- Diagnosis and Management of Malnutrition in Patients with Heart Failure.Journal of clinical medicine · 2023Review
- The role of dietary salt in metabolism and energy balance: Insights beyond cardiovascular disease.Diabetes, obesity & metabolism · 2023Review
- Association of thiamine administration and prognosis in critically ill patients with heart failure.Frontiers in pharmacology · 2023Article
- Editorial: The role of minerals and trace elements in chronic diseases.Frontiers in cell and developmental biology · 2023Article
- High Exogenous Antioxidant, Restorative Treatment (Heart) for Prevention of the Six Stages of Heart Failure: The Heart Diet.Antioxidants (Basel, Switzerland) · 2022Review
- Nutrition Assessment and Dietary Interventions in Heart Failure: JACC Review Topic of the Week.Journal of the American College of Cardiology · 2022Review
- Food insecurity and cardiovascular disease: Current trends and future directions.American journal of preventive cardiology · 2022Article
- Lack of Association between Inadequate Micronutrient Intake and Prognosis in Outpatients with Heart Failure.Nutrients · 2022Article
- Liver Protein Expression in NASH Mice on a High-Fat Diet: Response to Multi-Mineral Intervention.Frontiers in nutrition · 2022Article
- Selenium, Selenoproteins, and Heart Failure: Current Knowledge and Future Perspective.Current heart failure reports · 2021Review
- The association of deficiencies of water-soluble vitamin intake with health-related quality of life and prognosis in patients with heart failure.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Nutrition as Treatment Modality in Heart Failure.Current atherosclerosis reports · 2021Review
- Age- and sex-matched comparison of diet quality in patients with heart failure to similarly aged healthy older adults.Journal of nutritional science · 2021Article
- Insufficient Calorie Intake Worsens Post-Discharge Quality of Life and Increases Readmission Burden in Heart Failure.JACC. Heart failure · 2020Article
Corrections and comments
- Commented on by
Authors and funding
9 authors at 8 institutions in 3 countries.
Funding
Abstract
Background Dietary micronutrient deficiencies have been shown to predict event-free survival in other countries but have not been examined in patients with heart failure living in the United States. The purpose of this study was to determine whether number of dietary micronutrient deficiencies in patients with heart failure was associated with shorter event-free survival, defined as a combined end point of all-cause hospitalization and death. Methods and Results Four-day food diaries were collected from 246 patients with heart failure (age: 61.5±12 years; 67% male; 73% white; 45% New York Heart Association [NYHA] class III / IV ) and analyzed using Nutrition Data Systems for Research. Micronutrient deficiencies were determined according to methods recommended by the Institute of Medicine. Patients were followed for 1 year to collect data on all-cause hospitalization or death. Patients were divided according to number of dietary micronutrient deficiencies at a cut point of ≥7 for the high deficiency category versus <7 for the no to moderate deficiency category. In the full sample, 29.8% of patients experienced hospitalization or death during the year, including 44.3% in the high-deficiency group and 25.1% in the no/moderate group. The difference in survival distribution was significant (log rank, P=0.0065). In a Cox regression, micronutrient deficiency category predicted time to event with depression, NYHA classification, comorbidity burden, body mass index, calorie and sodium intake, and prescribed angiotensin-converting enzyme inhibitors, diuretics, or β-blockers included as covariates. Conclusions This study provides additional convincing evidence that diet quality of patients with heart failure plays an important role in heart failure outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.