ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Surveillance of Maternal Syphilis in China: Pregnancy Outcomes and Determinants of Congenital Syphilis.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Climate change and vertically transmissible infections in maternal and neonatal populations: a systematic review.Frontiers in global women's health · 2026Pooled it
- Factors influencing adult and adolescent completion of treatment for late syphilis: a mixed methods systematic review.Bulletin of the World Health Organization · 2025Pooled it
- Factors related to adverse pregnancy outcomes of maternal syphilis in Nanning, Guangxi, China 2016-2020.Scientific reports · 2025Article
- Delivering integrated and standardized services to eliminate mother-to-child transmission of sexually transmitted infections: experience of the E-Clinic model in a Chinese pilot district.Health policy and planning · 2025Article
- Syphilis Infection During Pregnancy: The Possible Effect on the Course of Pregnancy and Fetal Outcomes-A Case Report and Literature Review.Biomedicines · 2025Article
- [Effect of positive deviation on the diagnosis and treatment of gestational syphilis, and the prevention of congenital syphilis: A cohort study].Revista colombiana de obstetricia y ginecologia · 2024Article
- Article
- Syphilis and pregnancy.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Article
- Economic analysis of a new four-panel rapid screening test in antenatal care in Kenya, Rwanda, and Uganda.BMC health services research · 2023Article
- Towards the elimination of mother to child transmission of syphilis 2015-2020: practice and progress in Zhejiang province, eastern China.BMC pregnancy and childbirth · 2023Article
- Adverse pregnancy outcomes and associated risk factors among pregnant women with syphilis during 2013-2018 in Hunan, China.Frontiers in medicine · 2023Article
- Predicting adverse pregnancy outcomes of pregnant mothers with syphilis based on a logistic regression model: a retrospective study.Frontiers in public health · 2023Article
- Eliminating Mother-to-Child Transmission of Syphilis: Chinese Practice before and during COVID-19 Pandemics.Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih · 2022Article
- Prevalence ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- An analysis of the clinical features of children with early congenital Syphilis and Syphilitic Hepatitis.BMC pediatrics · 2021Article
- Gender Equity and Vertically Transmitted Infections: A Country-Level Analysis Across 153 Countries.Health equity · 2021Article
- Maternal syphilis treatment and pregnancy outcomes: a retrospective study in Jiangxi Province, China.BMC pregnancy and childbirth · 2020Article
- Screening and Treatment of Syphilis for Pregnant Women - China, 2011-2018.China CDC weekly · 2020Article
- The Effect of Different Treatment Regimens and Multiple Risk Factors on Adverse Pregnancy Outcomes among Syphilis-Seropositive Women in Guangzhou: A Retrospective Cohort Study.BioMed research international · 2020Article
- Differences in maternal characteristics and pregnancy outcomes between syphilitic women with and without partner coinfection.BMC pregnancy and childbirth · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND We sought to describe the epidemiological characteristics of pregnant women with syphilis in Beijing, China, and to investigate the determinants of adverse pregnancy outcomes, including congenital syphilis. MATERIAL AND METHODS We used data from laboratory-confirmed syphilis-infected women who delivered between 2013 and 2015 and were registered in China's Information Management System for Prevention of Mother-to-Child Transmission of Syphilis. Sociodemographic, clinical, and prevention predictors of adverse pregnancy outcomes (i.e., congenital syphilis, neonatal death, and neonatal asphyxia) were assessed using multivariable regression analyses. RESULTS Among 807 eligible pregnant women with syphilis in Beijing, the maternal syphilis ratios increased from 1.1 (in 2013) to 1.4 (in 2015) per 1000 live births, while adverse pregnancy outcomes decreased, including congenital syphilis (1.3% to 0.4%), neonatal deaths (1.3% to 0%), and neonatal asphyxia (0.9% to 0%). Both prevention and treatment interventions increased, including antenatal testing (93.5% to 93.9%), any treatment (76.6% to 85.2%), adequate treatment (51.1% to 65.1%), and treatment initiated in the first trimester (30.7% to 42.8%). In the logistic regression analysis, higher maternal rapid plasma reagin antibody titers (aOR=1.1 95%CI=1.0-1.1) and third-trimester syphilis diagnosis (aOR=1.7 95%CI=1.1-2.6) were independent risk factors for adverse pregnancy outcomes. Protective factors included being married (aOR=0.4; 95%CI=0.2-0.6) and adequate prenatal treatment (aOR=0.3; 95%CI=0.1-0.7). CONCLUSIONS Integrated strategies for maternal syphilis control were associated with improved outcomes but must be strengthened. Future efforts should include education and outreach for antenatal care for at-risk women, syphilis screening at first antenatal care visit, immediate initiation of treatment, and syphilis screening extended to women presenting with miscarriage or stillbirth.
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