Evidence map›Paper›PMID 30370809›Full record

SynthesisThe Journal of international medical research2018

Higher serum zinc levels may reduce the risk of cervical cancer in Asian women: A meta-analysis.

Yueying Xie, Junjie Wang, Xiaoya Zhao, Xuli Zhou, Xiaohui Nie, Chuncheng Li, Fulian Huang, Haibin Yuan

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Observational
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yueying Xie1 Department of Pathology, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
Junjie Wang2 Department of Gynaecology, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
Xiaoya Zhao1 Department of Pathology, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
Xuli Zhou1 Department of Pathology, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
Xiaohui Nie2 Department of Gynaecology, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
Chuncheng Li1 Department of Pathology, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
Fulian Huang2 Department of Gynaecology, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
Haibin Yuan3 Department of Paediatrics, the Maternal and Child Health Care Hospital of Xiangtan City, Hunan Province, China.
Hunan Provincial Maternal and Child Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis meta-analysis was conducted to examine the possible association between serum zinc concentration and cervical cancer risk.

methodsPubMed, WanFang, China National Knowledge Infrastructure, and SinoMed databases were searched for relevant articles published between January 1980 and September 2017. Results were combined using a random-effects model, and pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare serum zinc levels in patients with cervical cancer versus controls. Publication bias was evaluated using Begg's funnel plot and Egger's regression asymmetry test.

resultsTwelve articles regarding serum zinc levels and cervical cancer were included in this meta-analysis. Combined results showed that serum zinc levels in cervical cancer cases were significantly lower than in controls without cervical cancer (summary SMD -1.379, 95% CI -1.527, -1.231), with high heterogeneity ( I

conclusionsHigher serum zinc levels may be a protective factor for cervical cancer in Asian women.

Indexed as

Asian PeopleFemaleHumansUterine Cervical NeoplasmsZincZinccervical cancermeta-analysisSerumzinc levels

Identifiers

PMID30370809
PMCPMC6300959
OpenAlexW2898957102

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.