Evidence map›Paper›PMID 30370778›Full record

ArticleBioTechniques2019

Clarification and confocal imaging of the nonhuman primate placental micro-anatomy.

J A Sargent, Vhj Roberts, J E Gaffney, A E Frias

Open access · goldAbstract read
In one paragraph

Article in BioTechniques, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

J A SargentDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, USA.
Vhj RobertsDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR, USA.
J E GaffneyDivision of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR, USA.
A E FriasDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, USA.
Oregon National Primate Research Center · USOregon Health & Science University · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Development and validation of MR imaging methods for in vivo assessment of placental perfusion and oxygenationR01HD086331 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI FRIAS, ANTONIO E · 2015 to 2019
$2.6M
NICHD NIH HHS R01 HD086331NIH HHS P51 OD011092
6 · The paper itself

Abstract

Geometry of the placental villous vasculature is a key determinant of maternal-fetal nutrient exchange for optimal fetal growth. Recent advances in tissue clarification techniques allow for deep high-resolution imaging with confocal microscopy; however, the methodology lacks a signal:noise ratio of sufficient magnitude to allow for quantitative analysis. Thus, we sought to develop a reproducible method to investigate the 3D vasculature of the nonhuman primate placenta for subsequent data analysis. Fresh placental tissue was dissected, formalin fixed, clarified using a modified Visikol

Indexed as

AnimalsChorionic VilliFemaleFetal DevelopmentHumansImaging, Three-DimensionalMicroscopy, ConfocalPlacentaPregnancyPrimatesconfocal microscopyimmunohistochemistrynonhuman primateplacentatissue clarification

Identifiers

PMID30370778
PMCPMC6521839
OpenAlexW2951723127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.