Evidence map›Paper›PMID 30370679›Full record

ReviewWiley interdisciplinary reviews. RNA2019

Gaining insight into transcriptome-wide RNA population dynamics through the chemistry of 4-thiouridine.

Erin E Duffy, Jeremy A Schofield, Matthew D Simon

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. RNA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
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  4. Review
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  11. Transcriptome and Temporal Transcriptome Analyses in Single Cells.International journal of molecular sciences · 2024
    Review
  12. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Erin E DuffyDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.
Jeremy A SchofieldDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.
Matthew D SimonDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
Integrating RNAs into signaling pathways by engineering covalent RNA modificationDP2HD083992 · NICHD · YALE UNIVERSITY · PI SIMON, MATTHEW DAVID · 2014 to 2014
$2.5M
National Institute of Health T32GM007223National Science Foundation DGE1122492NICHD NIH HHS DP2 HD083992NIGMS NIH HHS T32 GM007223
6 · The paper itself

Abstract

Cellular RNA levels are the result of a juggling act between RNA transcription, processing, and degradation. By tuning one or more of these parameters, cells can rapidly alter the available pool of transcripts in response to stimuli. While RNA sequencing (RNA-seq) is a vital method to quantify RNA levels genome-wide, it is unable to capture the dynamics of different RNA populations at steady-state or distinguish between different mechanisms that induce changes to the steady-state (i.e., altered rate of transcription vs. degradation). The dynamics of different RNA populations can be studied by targeted incorporation of noncanonical nucleosides. 4-Thiouridine (s

Indexed as

AnimalsHumansRNAThiouridineTranscriptomeRNAThiouridinenucleoside recodingRNA metabolismRNA turnovertranscriptome dynamicstransient transcription

Identifiers

PMID30370679
PMCPMC6768404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.