Evidence map›Paper›PMID 30370544›Full record

ArticleMedical physics2019

Estimating the spectrum in computed tomography via Kullback-Leibler divergence constrained optimization.

Wooseok Ha, Emil Y Sidky, Rina Foygel Barber, Taly Gilat Schmidt, Xiaochuan Pan

Erratum issuedAbstract read
In one paragraph

Article in Medical physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  5. Article
  6. Article
  7. Image-domain Material Decomposition for Spectral CT using a Generalized Dictionary Learning.IEEE transactions on radiation and plasma medical sciences · 2021
    Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wooseok HaDepartment of Statistics, UC Berkeley, 473 Evans Hall, Berkeley, CA, 94720, USA.
Emil Y SidkyDepartment of Radiology, The University of Chicago, Chicago, IL, 60637, USA.
Rina Foygel BarberDepartment of Statistics, The University of Chicago, Chicago, IL, 60637, USA.
Taly Gilat SchmidtDepartment of Biomedical Engineering, Marquette University, Milwaukee, WI, 53201, USA.
Xiaochuan PanDepartment of Radiology, The University of Chicago, Chicago, IL, 60637, USA.

Funding

Advanced iterative image reconstruction for digital breast tomosynthesis - Resubmission 01R01EB026282 · NIBIB · UNIVERSITY OF CHICAGO · PI PAN, XIAOCHUAN, SIDKY, EMIL Y · 2018 to 2021
$2.1M
Digital Specimen Tomosynthesis for Volumetric Imaging of Lumpectomy SpecimensR01EB018102 · NIBIB · UNIVERSITY OF CHICAGO · PI PAN, XIAOCHUAN · 2014 to 2017
$2.0M
Development of Advanced C-arm Cone-Beam CT for the Treatment of Liver CancerR01CA182264 · NCI · UNIVERSITY OF CHICAGO · PI PAN, XIAOCHUAN · 2014 to 2017
$1.8M
Algorithm-Enabled Auto-Calibrating Quantitative Dual-Energy CTR21CA263660 · NCI · UNIVERSITY OF CHICAGO · PI PAN, XIAOCHUAN · 2022 to 2023
$414k
Advancing energy-resolved CT systems for imaging K-edge contrast agentsR21EB015094 · NIBIB · MARQUETTE UNIVERSITY · PI SCHMIDT, TALY GILAT · 2013 to 2014
$390k
Berkeley Institute for Data ScienceNCI NIH HHS R01 CA182264NCI NIH HHS R21 CA263660NIBIB NIH HHS R01 EB018102NIBIB NIH HHS R01 EB026282NIBIB NIH HHS R21 EB015094NIH HHS R01-CA182264NIH HHS R01-EB018102NIH HHS R21EB015094NSF DMS-1654076
6 · The paper itself

Abstract

purposeWe study the problem of spectrum estimation from transmission data of a known phantom. The goal is to reconstruct an x-ray spectrum that can accurately model the x-ray transmission curves and reflects a realistic shape of the typical energy spectra of the CT system.

methodsSpectrum estimation is posed as an optimization problem with x-ray spectrum as unknown variables, and a Kullback-Leibler (KL)-divergence constraint is employed to incorporate prior knowledge of the spectrum and enhance numerical stability of the estimation process. The formulated constrained optimization problem is convex and can be solved efficiently by use of the exponentiated-gradient (EG) algorithm. We demonstrate the effectiveness of the proposed approach on the simulated and experimental data. The comparison to the expectation-maximization (EM) method is also discussed.

resultsIn simulations, the proposed algorithm is seen to yield x-ray spectra that closely match the ground truth and represent the attenuation process of x-ray photons in materials, both included and not included in the estimation process. In experiments, the calculated transmission curve is in good agreement with the measured transmission curve, and the estimated spectra exhibits physically realistic looking shapes. The results further show the comparable performance between the proposed optimization-based approach and EM.

conclusionsOur formulation of a constrained optimization provides an interpretable and flexible framework for spectrum estimation. Moreover, a KL-divergence constraint can include a prior spectrum and appears to capture important features of x-ray spectrum, allowing accurate and robust estimation of x-ray spectrum in CT imaging.

Indexed as

AlgorithmsImage Processing, Computer-AssistedModels, TheoreticalTomography, X-Ray ComputedEMexponentiated-gradient algorithmKL divergencespectral calibrationx-ray spectrum

Identifiers

PMID30370544
PMCPMC6461446

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.