Evidence map›Paper›PMID 30370484›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2018

Naringenin mitigates titanium dioxide (TiO

Marília F Manchope, Nayara A Artero, Victor Fattori, Sandra S Mizokami, Dimitrius L Pitol, João P M Issa, Sandra Y Fukada, Thiago M Cunha, José C Alves-Filho, Fernando Q Cunha and 2 more

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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Marília F ManchopeDepartamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid Km480 PR445, Cx Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Nayara A ArteroDepartamento de Ciências Farmacêuticas, Centro de Ciências de Saúde, Universidade Estadual de Londrina, Londrina, Brazil.
Victor FattoriDepartamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid Km480 PR445, Cx Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Sandra S MizokamiDepartamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid Km480 PR445, Cx Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil.
Dimitrius L PitolDepartamento de Morfologia, Fisiologia e Patologia Básica, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
João P M IssaDepartamento de Morfologia, Fisiologia e Patologia Básica, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Sandra Y FukadaDepartamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Thiago M CunhaDepartamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
José C Alves-FilhoDepartamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Fernando Q CunhaDepartamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
Rubia CasagrandeDepartamento de Ciências Farmacêuticas, Centro de Ciências de Saúde, Universidade Estadual de Londrina, Londrina, Brazil.
Waldiceu A VerriDepartamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rod. Celso Garcia Cid Km480 PR445, Cx Postal 10.011, Londrina, Paraná, CEP 86057-970, Brazil. waverri@uel.br.ORCID http://orcid.org/0000-0003-2756-9283
Universidade de Ribeirão Preto · BRUniversidade Estadual de Londrina · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Programa de Pesquisa para o SUS (PPSUS) grant supported by Ministério da Ciência, Tecnologia e Inovação (MCTI), Secretaria da Ciência, Tecnologia e Ensino Superior (SETI), Decit/SCTIE/MS through CNPq with the support of Fundação Araucária and Secretaria da Saúde do Estado do Paraná (SESA-PR), and Parana State Government (Brazil) Convenio 041/2017
6 · The paper itself

Abstract

objectiveTo evaluate the effect and mechanisms of naringenin in TiO TREATMENT: Flavonoids are antioxidant and anti-inflammatory molecules with important anti-inflammatory effect. Mice were daily treated with the flavonoid naringenin (16.7-150 mg/kg, orally) for 30 days starting 24 h after intra-articular knee injection of 3 mg of TiO

methodsTiO

resultsNaringenin inhibited TiO

conclusionNaringenin ameliorates TiO

Indexed as

AnalgesicsAnimalsAnti-Inflammatory AgentsAntioxidantsArthritisChronic DiseaseCytokinesFlavanonesHyperalgesiaJointsMaleMiceNF-kappa BTitaniumAnalgesicsAnti-Inflammatory AgentsAntioxidantsCytokinesFlavanonesnaringeninNF-kappa BTitaniumtitanium dioxideArthritisArthroplastyAseptic inflammationFlavonoidsImplantPain

Identifiers

PMID30370484
OpenAlexW2898379806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.