Evidence map›Paper›PMID 30370453›Full record

SynthesisEsophagus : official journal of the Japan Esophageal Society2019

Clinical, endoscopic, and histologic characteristics of lymphocytic esophagitis: a systematic review.

Mohamad Habbal, Michael A Scaffidi, Amir Rumman, Rishad Khan, Mirusha Ramaj, Ahmed Al-Mazroui, Michael J Abunassar, Thurarshen Jeyalingam, Akshay Shetty, Gabor P Kandel and 2 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Esophagus : official journal of the Japan Esophageal Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review of therapeutic options for lymphocytic esophagitis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Lymphocytic oesophagitis: diagnosis and management.Clinical medicine (London, England) · 2023
    Review
  6. Article
  7. Recognition of esophagitis in endoscopic images using transfer learning.World journal of gastrointestinal endoscopy · 2022
    Article
  8. Article
  9. A case of lymphocytic esophagitis in a woman with multiple allergies.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohamad HabbalDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Michael A ScaffidiDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Amir RummanDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Rishad KhanDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Mirusha RamajDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Ahmed Al-MazrouiDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Michael J AbunassarDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Thurarshen JeyalingamDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Akshay ShettyDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Gabor P KandelDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada.
Catherine J StreutkerDepartment of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.
Samir C GroverDivision of Gastroenterology, St. Michael's Hospital, Department of Medicine, University of Toronto, St. Michael's Hospital, 30 Bond Street, 16-036 Cardinal Carter Wing, Toronto, ON, M5B 1W8, Canada. samir.grover@utoronto.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLymphocytic esophagitis (LyE) is a novel, yet poorly described, clinicopathologic entity. The aim of this systematic review was to characterize the demographic, clinical, endoscopic, and histologic features of LyE in observational studies of adult and pediatric patients.

designWe searched the Embase, MEDLINE, and SCOPUS databases for relevant studies in 2018. Two authors reviewed and extracted data from studies that met the inclusion and exclusion criteria.

resultsWe identified 20 studies for analysis of demographic, clinical, and endoscopic features of LyE. The mean age ranged from 9 to 67 years. When pooled, there were 231 (52.7%) patients with LyE that were female. The most common presenting symptom was dysphagia reported in 191 (48.8%) patients. On endoscopy, most patients with LyE tended to have abnormal findings (69.0%), which included erosive esophagitis, multiple esophageal rings, linear furrows, and narrow-caliber esophagus. In the 31 studies used to assess the histologic definition, the cut-off number of intraepithelial lymphocytes (IELs) was reported in 16 (51.6%) studies, peripapillary IEL specification in 18 (58.1%) studies, and presence of spongiosis in 6 (19.4%) studies.

conclusionWe identified a spectrum of demographic, clinical, and endoscopic findings characteristic of patients with LyE. A consensus on the diagnostic criteria of LyE is required.

Indexed as

AdolescentAdultAgedChildChild, PreschoolDeglutition DisordersEsophagitisEsophagoscopyFemaleGastroesophageal RefluxHumansLymphocytesLymphocytosisMaleMiddle AgedYoung AdultDiagnostic criteriaDysphagiaGastroesophageal reflux disease (GERD)Lymphocytic esophagitis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.