ArticleHematology, transfusion and cell therapy
Red blood cell alloimmunization among hospitalized patients: transfusion reactions and low alloantibody identification rate.
Article in Hematology, transfusion and cell therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 21 citations in OpenAlex.
- Optimization of the antibody identification interval in a high-volume transfusion centre.Vox sanguinis · 2026Article
- Frequency of Alloimmunization in Patients on Regular Blood Transfusion in Riyadh, Saudi Arabia: A Multicenter Retrospective Study.Journal of clinical medicine · 2026Article
- Article
- Phenotypic Identification of Blood Groups in Blood Donors: A Peruvian Multicenter Analysis.Journal of blood medicine · 2025Article
- Assessment of erythrocyte alloimmunization among patients treated at a Brazilian university hospital.Hematology, transfusion and cell therapy · 2024Article
- [Alloimmunisation in polytransfused patients with non-phenotyped red blood cells at the University Hospital Souro Sanou of Bobo Dioulasso (Burkina Faso)].The Pan African medical journal · 2022Article
- Red cell alloimmunization in multitransfused hepatobiliary patients at hospital Selayang.Asian journal of transfusion scienceArticle
- Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors.Asian journal of transfusion scienceArticle
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4 authors at 1 institution in 1 country.
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Abstract
backgroundUnexpected red blood cell alloantibodies can cause hemolytic transfusion reactions. In this study, the prevalence of alloimmunization, the rate of identification of alloantibodies and the rate of blood transfusion reactions among transfused patients were identified in a clinical emergency hospital in Brazil.
methodsTransfusions and clinical records of patients who had a positive indirect antiglobulin test between January and December 2013 were analyzed.
resultsOf 1169 patients who received blood transfusions, 28 had positive indirect antiglobulin tests, with one patient having two positive tests at different times, resulting in 29 positive tests during the period of this study. Alloantibodies were identified in 58.6% (17/29) of the cases. In 27.5% (8/29), identification was inconclusive and it was not possible to confirm alloimmunization. The rate of red blood cell alloimmunization was 1.71% (21/1169). Of 21 cases of alloimmunization, four (19%) were unidentified due to an unusual agglutination profile. All identified alloantibodies were clinically significant (10/17 anti-Rh, 5/17 anti-Kell and 2/17 anti-MNS). In two patients who had positive indirect antiglobulin tests, one had an unidentified alloantibody, and the other had an inconclusive test and developed a hemolytic transfusion reaction.
conclusionThe prevalence of clinically important red blood cell alloantibodies and hemolytic transfusion reactions among patients with unidentified alloantibodies suggests that specific laboratory techniques should be performed to identify alloantibodies in cases of pan-reactivity or autoantibodies to improve transfusion safety.
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