ReviewWorld journal of critical care medicine2018
Vitamin C in the critically ill - indications and controversies.
Review in World journal of critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Trial
- High-Dose Intravenous Vitamin C in Critical Illness: A Translational Exposure-Response Framework for Biomarker-Guided Precision Therapy.Medical sciences (Basel, Switzerland) · 2026Review
- Vitamin C as Scavenger of Reactive Oxygen Species during Healing after Myocardial Infarction.International journal of molecular sciences · 2024Review
- Article
- SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice.Experimental & molecular medicine · 2022Article
- α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration.Nutrients · 2022Article
- COVID-19, oxidative stress, and male reproductive dysfunctions: is vitamin C a potential remedy?Physiological research · 2022Review
- COVID-19, Oxidative Stress and Male Reproduction: Possible Role of Antioxidants.Antioxidants (Basel, Switzerland) · 2022Review
- Role of vitamin C in preventing of COVID-19 infection, progression and severity.AIMS microbiology · 2022Review
- The protective role of vitamin C in the management of COVID-19: A Review.The Journal of the Egyptian Public Health Association · 2021Review
- The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study.Antioxidants (Basel, Switzerland) · 2021Article
- No significant benefit of moderate-dose vitamin C on severe COVID-19 cases.Open medicine (Warsaw, Poland) · 2021Article
- Margins of beneficial daily dosage of supplements in prevention of COVID-19.EXCLI journal · 2021Article
- Overview of the possible role of vitamin C in management of COVID-19.Pharmacological reports : PR · 2020Review
- Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome.PharmaNutrition · 2020Review
- Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19.Revista espanola de anestesiologia y reanimacion · 2020Article
- Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)?Medicine in drug discovery · 2020Article
- Ascorbate as Prophylaxis and Therapy for COVID-19-Update From Shanghai and U.S. Medical Institutions.Global advances in health and medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ascorbic acid (vitamin C) elicits pleiotropic effects in the body. Among its functions, it serves as a potent anti-oxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that high-dose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.