Evidence map›Paper›PMID 30370183›Full record

ArticlePeerJ2018

Non-visual exploration of novel objects increases the levels of plasticity factors in the rat primary visual cortex.

Catia M Pereira, Marco Aurelio M Freire, José R Santos, Joanilson S Guimarães, Gabriella Dias-Florencio, Sharlene Santos, Antonio Pereira, Sidarta Ribeiro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Catia M Pereira *Instituto Internacional de Neurociências de Natal Edmond e Lily Safra, Macaiba, RN, Brasil.
Marco Aurelio M Freire *Programa de Pós-graduação em Saúde e Sociedade, Universidade do Estado do Rio Grande do Norte, Mossoró, RN, Brasil.
José R SantosDepartamento de Biociências, Universidade Federal de Sergipe, Itabaiana, SE, Brasil.
Joanilson S GuimarãesInstituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brasil.
Gabriella Dias-FlorencioInstituto do Cérebro, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.
Sharlene SantosInstituto do Cérebro, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.
Antonio PereiraFaculdade de Engenharia Elétrica, Universidade Federal do Pará, Belém, PA, Brasil.
Sidarta RibeiroInstituto do Cérebro, Universidade Federal do Rio Grande do Norte, Natal, RN, Brasil.
Instituto Federal do Rio Grande do Norte · BRUniversidade Federal do Pará · BRUniversidade do Estado do Rio Grande do Norte · BRUniversidade Federal de Sergipe · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHistorically, the primary sensory areas of the cerebral cortex have been exclusively associated with the processing of a single sensory modality. Yet the presence of tactile responses in the primary visual (V1) cortex has challenged this view, leading to the notion that primary sensory areas engage in cross-modal processing, and that the associated circuitry is modifiable by such activity. To explore this notion, here we assessed whether the exploration of novel objects in the dark induces the activation of plasticity markers in the V1 cortex of rats.

methodsAdult rats were allowed to freely explore for 20 min a completely dark box with four novel objects of different shapes and textures. Animals were euthanized either 1 (

resultsThe amount of neurons labeled with monoclonal antibodies against c-fos, egr-1 or pCaKMII increased significantly in V1 cortex after one hour of exploration in the dark. Three hours after exploration, the number of labeled neurons decreased to basal levels.

conclusionsOur results suggest that non-visual exploration induces the activation of immediate-early genes in V1 cortex, which is suggestive of cross-modal processing in this area. Besides, the increase in the number of neurons labeled with pCaKMII may signal a condition promoting synaptic plasticity.

Indexed as

CaMKIICross-modal processingImmediate-early genePhosphorylationVisual cortex

Identifiers

PMID30370183
PMCPMC6202959
OpenAlexW2896693099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.