Evidence map›Paper›PMID 30370067›Full record

ArticleJournal of clinical and translational science2018

Opportunities for life course research through the integration of data across Clinical and Translational Research Institutes.

Heidi A Hanson, William W Hay, Jonathan N Tobin, Shari L Barkin, Mark Atkins, Margaret R Karagas, Ann M Dozier, Cynthia Wetmore, Michael W Konstan, James E Heubi

Abstract read
In one paragraph

Article in Journal of clinical and translational science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heidi A HansonDepartment of Surgery, University of Utah School of Medicine, Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-0056-196X
William W HayDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
Jonathan N TobinThe Rockefeller University Center for Clinical and Translational Science and Clinical Directors Network (CDN), New York, NY, USA.
Shari L BarkinDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Mark AtkinsDepartment of Psychiatry, Institute for Juvenile Research, The University of Illinois at Chicago, Chicago, IL, USA.
Margaret R KaragasDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Ann M DozierDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.
Cynthia WetmoreDepartment of Pediatrics, Emory University, Children's Health Care of Atlanta, Atlanta, GA, USA.
Michael W KonstanDepartment of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
James E HeubiDivision of Gastroenterology, Pediatric Liver Care Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
Clinical and Translational Science Coordinating CenterU54TR000123 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2017
$14.2M
Project 3: Placental Biomarkers of Exposure and Outcome (Marsit)P01ES022832 · NIEHS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2018
$4.7M
Utah Building Interdisciplinary Resreach Careers in Women's Health Career Development ProgramK12HD085852 · NICHD · UNIVERSITY OF UTAH · PI VARNER, MICHAEL W. · 2015 to 2019
$2.3M
NCATS NIH HHS U54 TR000123NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR001067NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR001866NCATS NIH HHS UL1 TR002001NCATS NIH HHS UL1 TR002003NCATS NIH HHS UL1 TR002243NCATS NIH HHS UL1 TR002538NICHD NIH HHS K12 HD085852NIEHS NIH HHS P01 ES022832
6 · The paper itself

Abstract

introductionEarly life exposures affect health and disease across the life course and potentially across multiple generations. The Clinical and Translational Research Institutes (CTSIs) offer an opportunity to utilize and link existing databases to conduct lifespan research.

methodsA survey with Lifespan Domain Taskforce expert input was created and distributed to lead lifespan researchers at each of the 64 CTSIs. The survey requested information regarding institutional databases related to early life exposure, child-maternal health, or lifespan research.

resultsOf 64 CTSI, 88% provided information on a total of 130 databases. Approximately 59% (n=76/130) had an associated biorepository. Longitudinal data were available for 72% (n=93/130) of reported databases. Many of the biorepositories (n=44/76; 68%) have standard operating procedures that can be shared with other researchers.

conclusionsThe majority of CTSI databases and biorepositories focusing on child-maternal health and lifespan research could be leveraged for lifespan research, increased generalizability and enhanced multi-institutional research in the United States.

Indexed as

biorepositoryclinical and translational scienceEarly life exposurelife courselifespan

Identifiers

PMID30370067
PMCPMC6202009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.