ArticleIEEE transactions on bio-medical engineering2019
Micro-Coil Design Influences the Spatial Extent of Responses to Intracortical Magnetic Stimulation.
Article in IEEE transactions on bio-medical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- "Tone-Arm" Neuromodulation MEMS Microcoil for In Vivo Imaging.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Restore axonal conductance in a locally demyelinated axon with electromagnetic stimulation.Journal of neural engineering · 2025Article
- Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Patterned electrical brain stimulation by a wireless network of implantable microdevices.Nature communications · 2024Article
- Computational analysis of electrode structure and configuration for efficient and localized neural stimulation.Biomedical engineering letters · 2024Article
- Transparent and Conformal Microcoil Arrays for Spatially Selective Neuronal Activation.Device · 2024Article
- Thermal safety considerations for implantable micro-coil design.Journal of neural engineering · 2023Article
- Improving focality and consistency in micromagnetic stimulation.Frontiers in computational neuroscience · 2023Article
- Micro-magnetic stimulation of primary visual cortex induces focal and sustained activation of secondary visual cortex.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Article
- Finding the Location of Axonal Activation by a Miniature Magnetic Coil.Frontiers in computational neuroscience · 2022Article
- Nanotechnology Enables Novel Modalities for Neuromodulation.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Selective Activation of Cortical Columns Using Multichannel Magnetic Stimulation With a Bent Flat Microwire Array.IEEE transactions on bio-medical engineering · 2021Article
- MEMS inductor fabrication and emerging applications in power electronics and neurotechnologies.Microsystems & nanoengineering · 2021Review
- Micro-coil probes for magnetic intracortical neural stimulation: Trade-offs in materials and design.APL materials · 2021Article
- Recent progress on peripheral neural interface technology towards bioelectronic medicine.Bioelectronic medicine · 2020Review
- Spatially confined responses of mouse visual cortex to intracortical magnetic stimulation from micro-coils.Journal of neural engineering · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveElectrical stimulation via cortically implanted electrodes has been proposed to treat a wide range of neurological disorders. Effectiveness has been limited, however, in part due to the inability of conventional electrodes to activate specific types of neurons while avoiding other types. Recent demonstrations that magnetic stimulation from a micro-coil can selectively activate pyramidal neurons (PNs) while avoiding passing axons suggest the possibility that such an approach can overcome some this limitation and here we use computer simulations to explore how the micro-coil design influences the selectivity with which neurons are activated.
methodsA computational model was developed to compare the selectivity of magnetic stimulation induced by rectangular-, V-, and W-shaped coil designs. The more promising designs (V- and W-shapes) were fabricated for use in electrophysiological experiments including in vitro patch-clamp recording and calcium imaging (GCaMP6f) of mouse brain slices.
resultsBoth V- and W-shaped coils reliably activated layer 5 (L5) PNs but V-coils were more effective while W-coils were more selective. Activation thresholds with double-loop coils were approximately one-half those of single-loop coils. Calcium imaging revealed that both V- and W-coils better confine activation than electrodes.
conclusionIndividual design features can influence both the strength as well as the selectivity of micro-coils and can be accurately predicted by computer simulations. SIGNIFICANCE: Our results show that how coil design influences the response of cortical neurons to stimulation and are an important step toward the development of next-generation cortical prostheses.
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