Evidence map›Paper›PMID 30369314›Full record

ArticleJournal of the American Heart Association2018

Activin Receptor-Like Kinase 4 Haplodeficiency Mitigates Arrhythmogenic Atrial Remodeling and Vulnerability to Atrial Fibrillation in Cardiac Pathological Hypertrophy.

Qian Wang, Yihe Chen, Daoliang Zhang, Changyi Li, Xiaoqing Chen, Jianwen Hou, Yudong Fei, Yuepeng Wang, Yigang Li

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Research Progress of Myocardial Fibrosis and Atrial Fibrillation.Frontiers in cardiovascular medicine · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Qian Wang1 Department of Cardiology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China.
Yihe Chen1 Department of Cardiology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China.
Daoliang Zhang2 Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China.
Changyi Li1 Department of Cardiology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China.
Xiaoqing Chen3 Department of Cardiology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Jianwen Hou1 Department of Cardiology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China.
Yudong Fei1 Department of Cardiology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China.
Yuepeng Wang1 Department of Cardiology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China.
Yigang Li1 Department of Cardiology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai China.
Shanghai Jiao Tong University · CNXinHua Hospital · CNShanghai First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Activin receptor-like kinase 4 ( ALK 4) is highly expressed in mammal heart. Atrial fibrillation ( AF ) is closely related to ventricular pressure overload. Because pressure overload increases atrial pressure and leads to atrial remodeling, it would be informative to know whether ALK 4 exerts potential effects on atrial remodeling and AF vulnerability in a pressure-overload model. Methods and Results Wild-type littermates and ALK 4

Indexed as

CardiomegalyActivin Receptors, Type IAgedAnimalsAorta, AbdominalAtrial FibrillationAtrial RemodelingChemokine CCL2Chemotactic FactorsConnexin 43ConnexinsFemaleFibrosisGap Junction alpha-5 ProteinGenetic Predisposition to DiseaseHaploinsufficiencyActivin Receptors, Type IACVR1B protein, humanAcvr1b protein, mouseCcl2 protein, mouseChemokine CCL2Chemotactic FactorsConnexin 43ConnexinsGap Junction alpha-5 ProteinGJA1 protein, mouseInterleukin-6interleukin-6, mouseSmad2 ProteinSmad2 protein, mouseSmad3 ProteinSmad3 protein, mouseALK4atrial fibrillationcardiac hypertrophySmad2/3structural and electrical remodeling

Identifiers

PMID30369314
PMCPMC6201394
OpenAlexW2891769573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.