Evidence map›Paper›PMID 30369103›Full record

ReviewAdvanced healthcare materials2019

Dual Polymerizations: Untapped Potential for Biomaterials.

Daniel C Lee, Robert J Lamm, Alex N Prossnitz, Andrew J Boydston, Suzie H Pun

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel C LeeMolecular Engineering and Sciences Institute, University of Washington, 3946 W Stevens Way NE, Seattle, WA, 98105, USA.
Robert J LammDepartment of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA, 98105, USA.
Alex N ProssnitzDepartment of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA, 98105, USA.
Andrew J BoydstonDepartment of Chemistry, University of Washington, 4000 15th Ave NE, Seattle, WA, 98195, USA.
Suzie H PunDepartment of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA, 98105, USA.ORCID 0000-0003-1443-4996

Funding

Ultrasound-aided gene transfer to direct cortical neurogenesis after brain injuryR01NS064404 · NINDS · UNIVERSITY OF WASHINGTON · PI HORNER, PHILIP J, PUN, SUZIE H. · 2009 to 2018
$3.5M
Synthetic Hemostats for Trauma TreatmentR01HL139007 · NHLBI · UNIVERSITY OF WASHINGTON · PI PUN, SUZIE H., WHITE, NATHAN J · 2017 to 2020
$2.3M
POTENTIATING BREAST CANCER THERAPIES BY TARGETING TUMOR-ASSOCIATED MACROPHAGER01CA177272 · NCI · UNIVERSITY OF WASHINGTON · PI PUN, SUZIE H. · 2014 to 2019
$2.0M
DOD PR151175DOD SC130249NCI NIH HHS R01 CA177272NHLBI NIH HHS R01 HL139007NINDS NIH HHS R01 NS064404NSF 2013163249NSF 2016226159
6 · The paper itself

Abstract

Block copolymers with unique architectures and those that can self-assemble into supramolecular structures are used in medicine as biomaterial scaffolds and delivery vehicles for cells, therapeutics, and imaging agents. To date, much of the work relies on controlling polymer behavior by varying the monomer side chains to add functionality and tune hydrophobicity. Although varying the side chains is an efficient strategy to control polymer behavior, changing the polymer backbone can also be a powerful approach to modulate polymer self-assembly, rigidity, reactivity, and biodegradability for biomedical applications. There are many developments in the syntheses of polymers with segmented backbones, but these developments are not widely adopted as strategies to address the unique constraints and requirements of polymers for biomedical applications. This review highlights dual polymerization strategies for the synthesis of backbone-segmented block copolymers to facilitate their adoption for biomedical applications.

Indexed as

Biocompatible MaterialsFree RadicalsPolymerizationPolymersBiocompatible MaterialsFree RadicalsPolymersbiomaterialsblock copolymersdual polymerizationsorthogonal polymerizationstandem polymerizations

Identifiers

PMID30369103
PMCPMC6426662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.