ArticleJournal of clinical microbiology1987
Bovine milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritis.
Article in Journal of clinical microbiology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Pedimune in recurrent respiratory infection and diarrhoea--the Indian experience--the pride study.Indian journal of pediatrics · 2006Trial
- Trial
- Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection.The Journal of clinical investigation · 2013Article
- Perspectives on immunoglobulins in colostrum and milk.Nutrients · 2011Review
- Bovine colostral antibody against verotoxin 2 derived from Escherichia coli O157:H7: resistance to proteases and effects in beagle dogs.Comparative medicine · 2009Article
- Role of colostrum in gastrointestinal infections.Indian journal of pediatrics · 2008Article
- Effective prophylaxis against rotavirus diarrhea using a combination of Lactobacillus rhamnosus GG and antibodies.BMC microbiology · 2007Article
- The immunology of parasite infections in immunocompromised hosts.Parasite immunology · 2006Review
- Therapeutic potentials of bovine colostrums.Indian journal of pediatrics · 2005Review
- Treatment of infectious diarrhea in children.Paediatric drugs · 2003Review
- I, 5. Treatment of viral gastroenteritis.Perspectives in medical virology · 2003Article
- Rotavirus vaccine administered parenterally induces protective immunity.Journal of virology · 1993Article
- Antibodies to seven rotavirus serotypes in cord sera, maternal sera, and colostrum of German women.Journal of clinical microbiology · 1991Article
- Murine intestinal antibody response to heterologous rotavirus infection.Journal of clinical microbiology · 1991Article
- Passive immunization of hamsters against disease caused by Clostridium difficile by use of bovine immunoglobulin G concentrate.Infection and immunity · 1991Article
- VP4-specific intestinal antibody response to rotavirus in a murine model of heterotypic infection.Journal of virology · 1991Article
- Rotavirus serotypes 6 and 10 predominate in cattle.Journal of clinical microbiology · 1990Article
- Efficacy of an inactivated oil-adjuvanted rotavirus vaccine in the control of calf diarrhoea in beef herds in Argentina.Vaccine · 1989Article
- Bovine lactogenic immunity against cholera toxin-related enterotoxins and Vibrio cholerae outer membranes.Infection and immunity · 1989Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregnant cows were successfully hyperimmunized with all four human rotavirus serotypes, resulting in a 100-fold increase in neutralizing milk antibody titers over those of controls. Milk antibodies were isolated batchwise from 1,000 kg of pooled milk for the first 10 lactation days, yielding 10 kg of freeze-dried milk immunoglobulin concentrate consisting of 50% bovine milk immunoglobulins. Milk immunoglobulin concentrate showed neutralizing activities against all four human rotavirus serotypes that were 100 times higher than those in pooled human milk samples and 10 times higher than those in a commercial pooled immunoglobulin preparation from pooled human blood serum. In vitro neutralization tests showed that milk immunoglobulin concentrate had powerful antiviral activity, even against very high doses of infectious rotaviruses. Because the technology of the milk immunoglobulin concentrate ensures that it is innocuous and can be used for oral application, it is proposed that milk immunoglobulin concentrate be used to induce passive immunity to infantile rotavirus gastroenteritis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.